Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | VEGFA | P15692 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006801 | 0.81 | MAPK14 (0.54) | MEN1KMT2AMAPK14 | |
| SCHEMBL7003290 | 0.77 | CNR2 (0.41) | HPGDMAPTALDH1A1HTTHSD17B10 | |
| SCHEMBL7002892 | 0.75 | HTR2C (0.54) | HPGDMAPTALDH1A1HTTHSD17B10 | |
| SCHEMBL7003158 | 0.75 | MAPK14 (0.48) | MAPK14 | |
| SCHEMBL7004254 | 0.72 | DAO (0.46) | HPGDMAPTALDH1A1HTTHSD17B10 | |
| SCHEMBL29809414 | 0.69 | ACHE (0.59) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL1757848 | 0.69 | ACHE (0.59) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL27478800 | 0.68 | F2 (0.54) | HPGDMAPTALDH1A1HTTMEN1 | |
| SCHEMBL31021 | 0.68 | HTR6 (0.73) | KMT2APOLB | |
| SCHEMBL29509279 | 0.68 | HTR6 (0.73) | KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200439-B1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | NOVUSPHARMA SPA (IT) | 2003-06-25 | — | — | EP | disclosed |