Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 4/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005436 | 0.82 | MAPT (0.38) | HTR2AHTR2CKMORXFP1HTR7 | |
| SCHEMBL7006296 | 0.81 | TP53 (0.38) | HRH4TP53HTR2AHTR2CKMO | |
| SCHEMBL7006877 | 0.81 | HTR3E (0.37) | TP53HTR2AHTR2CRXFP1HTR7 | |
| SCHEMBL7006177 | 0.81 | DAO (0.36) | TDP2HRH4HTR2AHTR2CBRD4 | |
| SCHEMBL7003133 | 0.78 | CA2 (0.44) | PTPN1HTR2AHTR2CHTR7 | |
| SCHEMBL7006777 | 0.78 | HTR7 (0.39) | TDP2TP53RXFP1HTR7BRD4 | |
| SCHEMBL7004254 | 0.78 | DAO (0.46) | TP53BRD4CREBBPDAO | |
| SCHEMBL7007358 | 0.77 | CREBBP (0.39) | BRD4CREBBP | |
| SCHEMBL7005550 | 0.72 | CHEK1 (0.45) | TDP2PTPN1HTR2AHTR2CKMO | |
| SCHEMBL7006729 | 0.70 | ALOX5 (0.48) | HTR7CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200439-B1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | NOVUSPHARMA SPA (IT) | 2003-06-25 | — | — | EP | disclosed |