Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 11/20 | 0.50 |
| ▸ | PTGES | O14684 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005248 | 0.84 | RAB9A (0.54) | RAB9ANPC1KMT2ASMN1; SMN2ALOX5 | |
| SCHEMBL11553029 | 0.74 | ALOX5 (0.54) | SMN1; SMN2ALOX5PTGESL3MBTL1KDM4E | |
| SCHEMBL3262242 | 0.73 | SMN1; SMN2 (0.56) | RAB9ANPC1KMT2ASMN1; SMN2ALOX5 | |
| SCHEMBL7005884 | 0.72 | ALDH1A1 (0.50) | RAB9ANPC1KMT2ASMN1; SMN2HTT | |
| SCHEMBL7826782 | 0.72 | ALOX5 (0.81) | KMT2AALOX5PTGESALDH1A1KDM4E | |
| SCHEMBL2342953 | 0.71 | TUBB4A (0.63) | RAB9ANPC1KMT2ASMN1; SMN2HTT | |
| SCHEMBL4701791 | 0.71 | ALDH1A1 (0.57) | RAB9ANPC1SMN1; SMN2ALOX5PTGES | |
| SCHEMBL13495321 | 0.71 | SMN1; SMN2 (0.53) | RAB9ANPC1KMT2ASMN1; SMN2ALOX5 | |
| SCHEMBL753833 | 0.71 | TUBB4A (0.60) | RAB9ANPC1KMT2ASMN1; SMN2HTT | |
| SCHEMBL7114817 | 0.71 | RAB9A (0.64) | RAB9ANPC1KMT2ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363910-A2 | METHODS OF TREATING P38 KINASE-ASSOCIATED CONDITIONS AND PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002040486-A2 | METHODS OF TREATING p38 KINASE-ASSOCIATED CONDITIONS AND PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-05-23 | — | — | WO | disclosed |