Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.69 |
| ▸ | BRD4 | O60885 | 2/20 | 0.54 |
| ▸ | TDO2 | P48775 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CBX7 | O95931 | 2/20 | 0.45 |
| ▸ | CDYL | Q9Y232 | 2/20 | 0.45 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.45 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12440856 | 0.88 | IDO1 (0.54) | IDO1TDO2KMT2AMAPTCYP1A2 | |
| SCHEMBL699811 | 0.83 | IDO1 (0.71) | IDO1BRD4TDO2MAPTCYP1A2 | |
| SCHEMBL699106 | 0.82 | IDO1 (0.48) | IDO1BRD4TDO2KMT2AMAPT | |
| SCHEMBL15264189 | 0.78 | IDO1 (0.63) | IDO1BRD4TDO2MAPTCBX7 | |
| SCHEMBL25435983 | 0.78 | IDO1 (0.77) | IDO1BRD4TDO2MAPTGAA | |
| SCHEMBL16377152 | 0.77 | PGR (0.45) | IDO1KMT2AMAPTCYP1A2CYP2C19 | |
| SCHEMBL30132814 | 0.76 | CYP1A2 (0.53) | IDO1BRD4KMT2AMAPTCYP1A2 | |
| SCHEMBL25313851 | 0.76 | CYP1A2 (0.53) | IDO1BRD4KMT2AMAPTCYP1A2 | |
| SCHEMBL17370968 | 0.75 | ALDH1A1 (0.50) | IDO1KMT2AMAPTCYP1A2CYP2C19 | |
| SCHEMBL18722716 | 0.75 | GSK3B (0.67) | KMT2ACBX7CDYLCDYL2CDY1; CDY1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108329311-B | Tricyclic compound as selective estrogen receptor down-regulator and application thereof | 南京圣和药业股份有限公司 | 2022-02-22 | — | — | CN | disclosed |
| WO-2018130124-A1 | TRICYCLIC COMPOUND AS SELECTIVE ESTROGEN RECEPTOR DOWN-REGULATOR AND USE THEREOF | 南京圣和药业股份有限公司 | 2018-07-19 | — | — | WO | disclosed |
| US-8124788-B2 | Spirocyclic cyclohexane compounds with analgesic activity | GRUENENTHAL GMBH (DE) | 2012-02-28 | — | — | US | disclosed |
| EP-2010531-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES WITH ANALGESIC PROPERTIES | GRUENENTHAL GMBH (DE) | 2011-08-17 | — | — | EP | disclosed |
| US-20090111842-A1 | SPIROCYCLIC CYCLOHEXANE COMPOUNDS WITH ANALGESIC ACTIVITY | GRUENENTHAL GMBH (DE) | 2009-04-30 | — | — | US | disclosed |
| EP-2010531-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVE WITH ANALGESIC PROPERTIES | Grünenthal GmbH (DE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007124903-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVE WITH ANALGESIC PROPERTIES | Grünenthal GmbH (DE) | 2007-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111842-A1 | SPIROCYCLIC CYCLOHEXANE COMPOUNDS WITH ANALGESIC ACTIVITY | OPRK1, OPRL1, OPRD1 | IDO1 3506/4885BRD4 3884/4885TDO2 3086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.