Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 6/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 3/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007978 | 0.85 | HTR7 (0.45) | HTR7ADRA1DADRA1AADRA1BLDHA | |
| SCHEMBL7014065 | 0.85 | HTR7 (0.47) | HTR7PLK1ADRA1DADRA1AADRA1B | |
| SCHEMBL7007980 | 0.85 | HTR7 (0.45) | HTR7ADRA1DADRA1AADRA1BLDHA | |
| SCHEMBL4383409 | 0.84 | TLR8 (0.46) | MAPK14HTR7PLK1DHFRGPR139 | |
| SCHEMBL7009364 | 0.81 | HTR7 (0.49) | HTR7ADRA1DADRA1AADRA1B | |
| SCHEMBL7006329 | 0.80 | F7 (0.44) | HTR7LDHA | |
| SCHEMBL4375476 | 0.79 | HTR7 (0.65) | MAPK14HTR7ADORA2BADRA1DADRA1A | |
| SCHEMBL7007986 | 0.78 | HTR7 (0.43) | HTR7PLK1ADRA1DADRA1AADRA1B | |
| SCHEMBL7018081 | 0.77 | ALDH1A1 (0.46) | HTR7PLK1ADRA1DADRA1AADRA1B | |
| SCHEMBL7014716 | 0.77 | ALDH1A1 (0.41) | HTR7ADRA1DADRA1AADRA1BLDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280781-A4 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2003-08-06 | — | — | EP | disclosed |
| EP-1280781-A1 | 5-HT 7 RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001085701-A1 | 5-HT7 RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-15 | — | — | WO | disclosed |