Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 9/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007978 | 1.00 | HTR7 (0.45) | HTR7APPADRA1DADRA1AADRA1B | |
| SCHEMBL7014065 | 0.87 | HTR7 (0.47) | HTR7APPADRA1DADRA1AADRA1B | |
| SCHEMBL7006322 | 0.85 | MAPK14 (0.44) | HTR7ADRA1DADRA1AADRA1BLDHA | |
| SCHEMBL7009364 | 0.83 | HTR7 (0.49) | HTR7APPADRA1DADRA1AADRA1B | |
| SCHEMBL4376521 | 0.83 | TLR8 (0.48) | HTR7APPLDHANUDT1ALDH1A1 | |
| SCHEMBL7014716 | 0.83 | ALDH1A1 (0.41) | HTR7ADRA1DADRA1AADRA1BLDHA | |
| SCHEMBL7006329 | 0.82 | F7 (0.44) | HTR7LDHAALDH1A1 | |
| SCHEMBL7007986 | 0.81 | HTR7 (0.43) | HTR7ADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL7011283 | 0.81 | HTR7 (0.43) | HTR7APPADRA1DADRA1AADRA1B | |
| SCHEMBL7018081 | 0.80 | ALDH1A1 (0.46) | HTR7APPADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280781-A4 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2003-08-06 | — | — | EP | disclosed |
| EP-1280781-A1 | 5-HT 7 RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001085701-A1 | 5-HT7 RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-15 | — | — | WO | disclosed |