Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 9/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | TPH1 | P17752 | 1/20 | 0.40 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018081 | 0.89 | ALDH1A1 (0.46) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL7007978 | 0.83 | HTR7 (0.45) | HTR7ADRA1DADRA1AADRA1BAPP | |
| SCHEMBL7007986 | 0.83 | HTR7 (0.43) | HTR7ADRA1DADRA1AADRA1B | |
| SCHEMBL7007980 | 0.83 | HTR7 (0.45) | HTR7ADRA1DADRA1AADRA1BAPP | |
| SCHEMBL7014065 | 0.83 | HTR7 (0.47) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL7014716 | 0.81 | ALDH1A1 (0.41) | HTR7ADRA1DADRA1AADRA1B | |
| SCHEMBL4375604 | 0.81 | TLR8 (0.53) | HTR7SMN1; SMN2ADRA1DADRA1AADRA1B | |
| SCHEMBL7006322 | 0.81 | MAPK14 (0.44) | HTR7ADRA1DADRA1AADRA1B | |
| SCHEMBL7006329 | 0.78 | F7 (0.44) | HTR7TPH1 | |
| SCHEMBL4373125 | 0.76 | HTR7 (0.74) | HTR7ADRA1DADRA1AADRA1BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280781-A4 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2003-08-06 | — | — | EP | disclosed |
| EP-1280781-A1 | 5-HT 7 RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001085701-A1 | 5-HT7 RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-15 | — | — | WO | disclosed |