Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006414 | 0.85 | ESR1 (0.39) | ALDH1A1KDM4ETSHRSMN1; SMN2ESR1 | |
| SCHEMBL7006166 | 0.84 | ESR1 (0.38) | CRHBPCRHR2ALDH1A1SMN1; SMN2ESR1 | |
| SCHEMBL7002598 | 0.84 | CRHBP (0.53) | CRHBPCRHR2F2RL3ALDH1A1KDM4E | |
| SCHEMBL7003687 | 0.83 | ESR1 (0.37) | SMN1; SMN2ESR1 | |
| SCHEMBL7000138 | 0.82 | ESR1 (0.36) | ESR1 | |
| SCHEMBL7010259 | 0.80 | ESR1 (0.39) | ALDH1A1SMN1; SMN2ESR1 | |
| SCHEMBL7003285 | 0.78 | ESR1 (0.38) | ALDH1A1TSHRSMN1; SMN2ESR1 | |
| SCHEMBL7562047 | 0.78 | TNF (0.37) | P2RX3LMNAESR1 | |
| SCHEMBL7555960 | 0.74 | TDP1 (0.38) | F2RL3ALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL5233806 | 0.73 | MAPK8 (0.46) | KDM4ETSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355886-A1 | FUSED HETEROCYCLIC COMPOUNDS | Takeda Chemical Industries, Ltd. (JP) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002062764-A9 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-10-10 | — | — | WO | disclosed |
| WO-2002062764-A1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-08-15 | — | — | WO | disclosed |