Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
| ▸ | VDR | P11473 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006414 | 0.91 | ESR1 (0.39) | ESR1BAZ2BBAZ2AL3MBTL1GPR35 | |
| SCHEMBL7000138 | 0.88 | ESR1 (0.36) | ESR1BAZ2BBAZ2AL3MBTL1GPR35 | |
| SCHEMBL7006166 | 0.84 | ESR1 (0.38) | ESR1BAZ2BBAZ2AL3MBTL1THRB | |
| SCHEMBL7010259 | 0.84 | ESR1 (0.39) | ESR1BAZ2BBAZ2AL3MBTL1GPR35 | |
| SCHEMBL7004657 | 0.84 | BAZ2B (0.39) | ESR1BAZ2BBAZ2AL3MBTL1GPR35 | |
| SCHEMBL7006924 | 0.83 | CRHBP (0.44) | ESR1SMN1; SMN2 | |
| SCHEMBL7562047 | 0.80 | TNF (0.37) | ESR1MCL1 | |
| SCHEMBL7003285 | 0.78 | ESR1 (0.38) | ESR1BAZ2BBAZ2ATHRBNPC1 | |
| SCHEMBL7555501 | 0.78 | GPR35 (0.36) | BAZ2BBAZ2AGPR35POLB | |
| SCHEMBL7592050 | 0.77 | THRA (0.36) | THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355886-A1 | FUSED HETEROCYCLIC COMPOUNDS | Takeda Chemical Industries, Ltd. (JP) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002062764-A9 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-10-10 | — | — | WO | disclosed |
| WO-2002062764-A1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-08-15 | — | — | WO | disclosed |