SCHEMBL7006949

SCHEMBL7006949

Clc1cccc(-c2[c]cccc2Br)c1

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.42
TAAR1 Q96RJ0 1/20 0.37
NOTUM Q6P988 4/20 0.35
ESR2 Q92731 1/20 0.35
NPC1 O15118 1/20 0.35
TP53 P04637 1/20 0.35
TSHR P16473 1/20 0.35
NFKB1 P19838 1/20 0.35
RAB9A P51151 1/20 0.35
NFKB2 Q00653 1/20 0.35
RELA Q04206 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
IDO1 P14902 4/20 0.34
MAOB P27338 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9649078 0.85 TSHR (0.31) TSHR
SCHEMBL9648703 0.81 ALOX5 (0.44) ALOX5TAAR1NOTUMESR2NPC1
SCHEMBL9265689 0.79 CYP1A2 (0.38) ALOX5
SCHEMBL7873510 0.79 ESR2 (0.46) ALOX5TAAR1ESR2TP53IDO1
SCHEMBL16058080 0.79 ALOX5 (0.42) ALOX5TAAR1NOTUMESR2NPC1
SCHEMBL6841248 0.79 AHR (0.45) NOTUMNPC1TP53NFKB1RAB9A
SCHEMBL16719910 0.79 ALOX5 (0.55) ALOX5TAAR1NOTUMESR2NPC1
SCHEMBL11705130 0.77 ALDH1A1 (0.44) TP53NFKB1RAB9ANFKB2RELA
SCHEMBL5321256 0.75 DHPS (0.44) ALOX5NOTUMNPC1TP53TSHR
SCHEMBL9716169 0.75 TAAR1 (0.41) ALOX5TAAR1ESR2IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1315716-A1 BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE, AND METHODS FOR THE PRODUCTION THEREOF Boehringer Ingelheim Pharma GmbH & Co.KG (DE) 2003-06-04 EP claimed
EP-1315718-A1 BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE, AND METHODS FOR THE PRODUCTION THEREOF Boehringer Ingelheim Pharma GmbH & Co.KG (DE) 2003-06-04 EP claimed
WO-2002018372-A1 BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE, AND METHODS FOR THE PRODUCTION THEREOF BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2002-03-07 WO claimed
WO-2002018370-A1 BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE, AND METHODS FOR THE PRODUCTION THEREOF BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2002-03-07 WO claimed
EP-0835242-A1 THIOAMIDES S-OXIDES FOR USE AS PESTICIDES Novartis AG (CH) 1998-04-15 EP claimed
WO-1997000859-A1 THIOAMIDES S-OXIDES FOR USE AS PESTICIDES NOVARTIS AG (CH) 1997-01-09 WO claimed
EP-1315718-A1 BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE, AND METHODS FOR THE PRODUCTION THEREOF Boehringer Ingelheim Pharma GmbH & Co.KG (DE) 2003-06-04 EP disclosed
WO-2002018372-A1 BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE, AND METHODS FOR THE PRODUCTION THEREOF BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2002-03-07 WO disclosed
WO-1988004658-A1 10-(SUBSTITUTED PHENYL)-3-ALKYLFLAVIN DERIVATIVES HAVING ANTIPROTOZOAL, ANTIPROLIFERATIVE AND ANTIINFLAMMATORY ACTIVITY THE AUSTRALIAN NATIONAL UNIVERSITY (AU) 1988-06-30 WO disclosed