Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A1 | P53985 | 9/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.57 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 4/20 | 0.40 |
| ▸ | PDE1A | P54750 | 4/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | SLC16A7 | O60669 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.38 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5864831 | 0.82 | SLC16A1 (0.58) | SLC16A1CYP2C9CYP3A4PDE2APDE1A | |
| SCHEMBL7497166 | 0.81 | SLC16A1 (0.45) | SLC16A1CYP2C9CYP3A4PDE2APDE1A | |
| SCHEMBL7006986 | 0.79 | SLC16A1 (0.43) | SLC16A1CYP2C9CYP3A4PDE2APDE1A | |
| SCHEMBL3833017 | 0.79 | SLC16A1 (0.75) | SLC16A1CYP2C9CYP3A4SLC16A7MAPKAPK2 | |
| SCHEMBL7008583 | 0.79 | TBXAS1 (0.42) | SLC16A1CYP2C9CYP3A4PDE2APDE1A | |
| SCHEMBL3827986 | 0.78 | SLC16A1 (0.73) | SLC16A1CYP2C9CYP3A4SLC16A7MAPKAPK2 | |
| SCHEMBL5864692 | 0.77 | SLC16A1 (0.56) | SLC16A1CYP2C9CYP3A4SLC16A7MAPKAPK2 | |
| SCHEMBL5865214 | 0.77 | ALDH1A1 (0.45) | SLC16A1CYP2C9CYP3A4MAPKAPK2CAMK2B | |
| SCHEMBL5864889 | 0.77 | SLC16A1 (0.42) | SLC16A1CYP2C9CYP3A4METPDE2A | |
| SCHEMBL5864895 | 0.76 | PDE3B (0.47) | SLC16A1CYP2C9CYP3A4SLC16A7MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107973-B1 | NOVEL THIENO[2,3-d]PYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION AND USE THEREOF IN THERAPY | ASTRAZENECA AB (SE) | 2003-11-05 | — | — | EP | claimed |