Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 3/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 3/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5646 | 0.81 | PDE2A (0.61) | KDM4EALDH1A1HPGDPDE1APDE1B | |
| SCHEMBL19583186 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1HPGDPDE1APDE1B | |
| SCHEMBL4796596 | 0.78 | PDE1A (0.46) | KDM4EALDH1A1HPGDPDE1APDE1B | |
| SCHEMBL6234430 | 0.77 | PDE5A (0.64) | KDM4EALDH1A1HPGDPDE1APDE1B | |
| SCHEMBL2053839 | 0.76 | PDE5A (0.42) | KDM4EALDH1A1HPGDPDE1APDE1B | |
| SCHEMBL4623653 | 0.75 | PDE5A (0.43) | KDM4EALDH1A1HPGDPDE1APDE1B | |
| SCHEMBL3110928 | 0.75 | PNP (0.48) | KDM4EALDH1A1HPGDPDE2AMEN1 | |
| SCHEMBL2954176 | 0.74 | ADORA1 (0.51) | KDM4EALDH1A1HPGDPDE1APDE1B | |
| SCHEMBL9646522 | 0.74 | KDM4E (0.44) | KDM4EALDH1A1HPGDPDE1APDE1B | |
| SCHEMBL7007230 | 0.73 | MEN1 (0.50) | KDM4EALDH1A1HPGDPDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10760049-B2 | Generation of neural stem cells from undifferentiated human embryonic stem cells | ES CELL INTERNATIONAL PTE LTD. (SG) | 2020-09-01 | — | — | US | disclosed |
| US-20170335278-A1 | GENERATION OF NEURAL STEM CELLS FROM UNDIFFERENTIATED HUMAN EMBRYONIC STEM CELLS | ES CELL INTERNATIONAL PTE LTD. (SG) | 2017-11-23 | — | — | US | disclosed |
| US-9650605-B2 | Generation of neural stem cells from undifferentiated human embryonic stem cells | ES CELL INTERNATIONAL PTE LTD. (SG) | 2017-05-16 | — | — | US | disclosed |
| EP-2652125-B1 | INSULIN PRODUCING CELLS DERIVED FROM PLURIPOTENT STEM CELLS | KADIMASTEM LTD (IL) | 2017-04-26 | — | — | EP | disclosed |
| US-9404087-B2 | Insulin producing cells derived from pluripotent stem cells | KADIMASTEM LTD. (IL) | 2016-08-02 | — | — | US | disclosed |
| EP-2652125-A1 | INSULIN PRODUCING CELLS DERIVED FROM PLURIPOTENT STEM CELLS | Kadimastem Ltd. (IL) | 2013-10-23 | — | — | EP | disclosed |
| US-20130273013-A1 | INSULIN PRODUCING CELLS DERIVED FROM PLURIPOTENT STEM CELLS | KADIMASTEM LTD. (IL) | 2013-10-17 | — | — | US | disclosed |
| WO-2012081029-A1 | INSULIN PRODUCING CELLS DERIVED FROM PLURIPOTENT STEM CELLS | KADIMASTEM LTD. (IL) | 2012-06-21 | — | — | WO | disclosed |
| US-20120122211-A1 | GENERATION OF NEURAL STEM CELLS FROM UNDIFFERENTIATED HUMAN EMBRYONIC STEM CELLS | ES CELL INTERNATIONAL PTE LTD. (SG) | 2012-05-17 | — | — | US | disclosed |
| US-8133730-B2 | Directing neural fate in a human neural progenitor cell hNPC in vitro by culturing the hNPC in the presence of a neural fate inducer selected from FGF-1, FGF-2, FGF-6, FGF-8, FGF-9, FGF-98, FGF-17, wherein the neural progenitor cell has been treated, prior to said culturing, with noggin | ES CELL INTERNATIONAL PTE LTD (SG) | 2012-03-13 | — | — | US | disclosed |
| EP-2360241-A1 | Stem cells | ES Cell International Pte Ltd. (SG) | 2011-08-24 | — | — | EP | disclosed |
| EP-2327762-A1 | Stem cells | ES Cell International Pte Ltd. (SG) | 2011-06-01 | — | — | EP | disclosed |
| US-7604992-B2 | Generation of neural stem cells from undifferentiated human embryonic stem cells | ES CELL INTERNATIONAL PTE LTD. (SG) | 2009-10-20 | — | — | US | disclosed |
| US-20090004736-A1 | GENERATION OF NEURAL STEM CELLS UNDIFFERENTIATED HUMAN EMBRYONIC STEM CELLS | ES CELL INTERNATIONAL PTE LTD. (SG) | 2009-01-01 | — | — | US | disclosed |
| US-20050255589-A1 | Directing neural fate in a human neural progenitor cell hNPC in vitro by culturing the hNPC in the presence of a neural fate inducer selected from FGF-1, FGF-2, FGF-6, FGF-8, FGF-9, FGF-98, FGF-17, wherein the neural progenitor cell has been treated, prior to said culturing, with noggin | ES CELL INTERNATIONAL PTE LTD. (SG) | 2005-11-17 | — | — | US | disclosed |
| EP-1511839-A4 | GENERATION OF NEURAL STEM CELLS FROM UNDIFFERENTIATED HUMAN EMBRYONIC STEM CELLS | ES CELL INT PTE LTD (SG) | 2005-11-16 | — | — | EP | disclosed |
| EP-1511839-A1 | GENERATION OF NEURAL STEM CELLS FROM UNDIFFERENTIATED HUMAN EMBRYONIC STEM CELLS | ES Cell International Pte Ltd. (SG) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003104444-A1 | GENERATION OF NEURAL STEM CELLS FROM UNDIFFERENTIATED HUMAN EMBRYONIC STEM CELLS | ES CELL INTERNATIONAL PTE LTD (AU) | 2003-12-18 | — | — | WO | disclosed |