Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | PDE1A | P54750 | 3/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5646 | 0.81 | PDE2A (0.61) | PDE5AMEN1KMT2APDE1APDE1B | |
| SCHEMBL19583186 | 0.79 | KDM4E (0.43) | PDE5AMEN1KMT2APDE1APDE1B | |
| SCHEMBL7007230 | 0.79 | MEN1 (0.50) | PDE5AMEN1KMT2APDE1APDE1B | |
| SCHEMBL4796596 | 0.78 | PDE1A (0.46) | PDE5AMEN1KMT2APDE1APDE1B | |
| SCHEMBL14889319 | 0.78 | PDE5A (1.00) | PDE5AMEN1KMT2APDE1APDE1B | |
| SCHEMBL272517 | 0.77 | KDM4E (0.41) | PDE5AMEN1KMT2APDE1APDE1B | |
| SCHEMBL2053839 | 0.76 | PDE5A (0.42) | PDE5AMEN1KMT2APDE1APDE1B | |
| SCHEMBL4623653 | 0.75 | PDE5A (0.43) | PDE5AMEN1KMT2APDE1APDE1B | |
| SCHEMBL2954176 | 0.74 | ADORA1 (0.51) | PDE5AMEN1KMT2APDE1APDE1B | |
| SCHEMBL9646522 | 0.74 | KDM4E (0.44) | PDE5AMEN1KMT2APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050244829-A1 | Method of screening insulin resistance inproving drug | ASTELLAS PHARMA INC. (JP) | 2005-11-03 | — | — | US | disclosed |
| EP-1533368-A1 | METHOD OF SCREENING INSULIN RESISTANCE IMPROVING DRUG | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2005-05-25 | — | — | EP | disclosed |
| US-5888811-A | ISOLATED NUCLEIC ACIDS; GENETIC ENGINEERING | DUPONT PHARMACEUTICALS COMPANY (US) | 1999-03-30 | — | — | US | disclosed |