Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 3/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.40 |
| ▸ | PDE2A | O00408 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5646 | 0.80 | PDE2A (0.61) | PDE5AKDM4EALDH1A1HPGDPDE1A | |
| SCHEMBL19583186 | 0.78 | KDM4E (0.43) | PDE5AKDM4EALDH1A1HPGDPDE1A | |
| SCHEMBL4796596 | 0.77 | PDE1A (0.46) | PDE5AKDM4EALDH1A1HPGDPDE1A | |
| SCHEMBL6234430 | 0.76 | PDE5A (0.64) | PDE5AKDM4EALDH1A1HPGDPDE1A | |
| SCHEMBL272517 | 0.76 | KDM4E (0.41) | PDE5AKDM4EALDH1A1HPGDPDE1A | |
| SCHEMBL4623653 | 0.74 | PDE5A (0.43) | PDE5AKDM4EALDH1A1HPGDPDE1A | |
| SCHEMBL2954176 | 0.73 | ADORA1 (0.51) | PDE5AKDM4EALDH1A1HPGDPDE1A | |
| SCHEMBL9646522 | 0.73 | KDM4E (0.44) | PDE5AKDM4EALDH1A1HPGDPDE1A | |
| SCHEMBL7007230 | 0.72 | MEN1 (0.50) | PDE5AKDM4EALDH1A1HPGDPDE1A | |
| SCHEMBL3110928 | 0.71 | PNP (0.48) | PDE5AKDM4EALDH1A1HPGDPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726603-A1 | BROWN FAT CELL COMPOSITIONS AND METHODS | Biorestorative Therapies, Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| WO-2013003595-A1 | BROWN FAT CELL COMPOSITIONS AND METHODS | BIORESTORATIVE THERAPIES, INC. (US) | 2013-01-03 | — | — | WO | disclosed |
| EP-2509992-A2 | TREATMENTS FOR GASTROINTESTINAL DISORDERS | Ironwood Pharmaceuticals, Inc. (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011071927-A2 | TREATMENTS FOR GASTROINTESTINAL DISORDERS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-16 | — | — | WO | disclosed |
| WO-2004069172-A2 | MULTILINEAGE-INDUCIBLE CELLS AND USES THEREOF | The Government of the United States of America as represented by the Department of Veterans Affairs (US) | 2004-08-19 | — | — | WO | disclosed |
| EP-0894133-A2 | NEUROPEPTIDE Y RECEPTOR Y5 AND NUCLEIC ACID SEQUENCE | Bayer Corporation (US) | 1999-02-03 | — | — | EP | disclosed |
| WO-1997037998-A2 | NEUROPEPTIDE Y RECEPTOR Y5 AND NUCLEIC ACID SEQUENCE | BAYER CORPORATION (US) | 1997-10-16 | — | — | WO | disclosed |