Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SSTR2 | P30874 | 5/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009169 | 0.74 | CHEK2 (0.33) | SSTR2PIM1PIM2CHEK2HSP90AA1 | |
| SCHEMBL7096511 | 0.74 | HRH3 (0.54) | HRH3SMN1; SMN2 | |
| SCHEMBL11449282 | 0.73 | PIM1 (0.47) | ALDH1A1PIM1PIM2CYP1A2CYP2D6 | |
| SCHEMBL8612335 | 0.72 | HTR7 (0.44) | ALDH1A1MAPTHRH3HTR2AHTR2C | |
| SCHEMBL12491869 | 0.70 | CHRNB4 (0.39) | ALDH1A1MAPTCHEK1MKNK1 | |
| SCHEMBL11467927 | 0.69 | CHRNB4 (0.50) | ALDH1A1PIM1PIM2MKNK1SMN1; SMN2 | |
| SCHEMBL18152767 | 0.69 | HTR2C (0.40) | ALDH1A1MAPTPIM1PIM2HTR2A | |
| SCHEMBL8615064 | 0.68 | ALDH1A1 (0.37) | ALDH1A1MAPTHRH3HTR2AHTR2C | |
| SCHEMBL8617442 | 0.68 | CHRNB4 (0.46) | — | |
| SCHEMBL8613696 | 0.68 | HRH3 (0.44) | ALDH1A1MAPTHRH3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |