Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 9/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | RARA | P10276 | 2/20 | 0.35 |
| ▸ | RARB | P10826 | 2/20 | 0.35 |
| ▸ | RARG | P13631 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012350 | 0.86 | ALDH1A1 (0.43) | RORCROCK2MEN1KMT2AALDH1A1 | |
| SCHEMBL7010907 | 0.86 | RORC (0.50) | RORCROCK2 | |
| Hydrochloric Acid SCHEMBL7845602 | 0.85 | ALDH1A1 (0.42) | RORCROCK2MEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7014597 | 0.85 | RORC (0.49) | RORCROCK2 | |
| SCHEMBL7656812 | 0.83 | CYP26A1 (0.38) | RORCROCK2MEN1KMT2AALDH1A1 | |
| SCHEMBL7993332 | 0.80 | ROCK2 (0.45) | ROCK2MEN1KMT2AALDH1A1CYP26A1 | |
| SCHEMBL7011258 | 0.78 | TP53 (0.39) | RORCMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7010421 | 0.78 | KCNQ3 (0.47) | RORCKMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7012972 | 0.78 | KMT2A (0.43) | RORCMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7009245 | 0.76 | MEN1 (0.42) | MEN1KMT2AALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |