SCHEMBL7007699

SCHEMBL7007699

CCOC(=O)c1c(O)c2cc(=O)ccc-2cn1CC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRHBP P24387 1/20 0.39
CRHR2 Q13324 1/20 0.39
ALDH1A1 P00352 3/20 0.39
MAPT P10636 2/20 0.39
GAA P10253 1/20 0.39
CA12 O43570 4/20 0.35
CA1 P00915 4/20 0.35
CA2 P00918 4/20 0.35
CA7 P43166 4/20 0.35
CA9 Q16790 4/20 0.35
CA14 Q9ULX7 4/20 0.35
PKM P14618 1/20 0.35
CHRNA7 P36544 1/20 0.35
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
F2RL3 Q96RI0 1/20 0.34
BAZ2B Q9UIF8 1/20 0.34
BAZ2A Q9UIF9 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7001088 0.83 NPC1 (0.36) ALDH1A1MAPTPKMESR1CYP1A2
SCHEMBL7007295 0.83 PTPN11 (0.37) CRHBPCRHR2ALDH1A1MAPTGAA
SCHEMBL7002721 0.82 JMJD6 (0.33) CRHBPCRHR2ALDH1A1MAPTPKM
SCHEMBL7559797 0.80 ALDH1A1 (0.38) CRHBPCRHR2ALDH1A1MAPTGAA
SCHEMBL7560338 0.77 CRHBP (0.43) CRHBPCRHR2ALDH1A1MAPTGAA
SCHEMBL7556806 0.76 BAZ2B (0.38) CRHBPCRHR2ALDH1A1MAPTGAA
SCHEMBL7561375 0.76 TDP1 (0.42) CRHBPCRHR2ALDH1A1MAPTGAA
SCHEMBL7564220 0.73 MAPT (0.38) CRHBPCRHR2ALDH1A1MAPTGAA
SCHEMBL7556201 0.70 MAPT (0.38) CRHBPCRHR2ALDH1A1MAPTGAA
SCHEMBL7003154 0.69 PTPN11 (0.37) ALDH1A1MAPTGAACA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1355886-A1 FUSED HETEROCYCLIC COMPOUNDS Takeda Chemical Industries, Ltd. (JP) 2003-10-29 EP disclosed
WO-2002062764-A1 FUSED HETEROCYCLIC COMPOUNDS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-08-15 WO disclosed