Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014557 | 0.81 | PDE1A (0.42) | SLC16A1ALDH1A1LMNAHTT | |
| SCHEMBL5864573 | 0.80 | PDE3B (0.44) | SLC16A1ALDH1A1LMNAHTT | |
| SCHEMBL7007892 | 0.73 | ALDH1A1 (0.45) | ALDH1A1LMNA | |
| SCHEMBL7012658 | 0.73 | ALDH1A1 (0.43) | ALDH1A1LMNA | |
| SCHEMBL7006914 | 0.72 | PDE2A (0.45) | ALDH1A1LMNAHTT | |
| SCHEMBL6636939 | 0.68 | HTR4 (0.39) | ADORA2BSLC16A1ALDH1A1LMNAHTT | |
| SCHEMBL7856402 | 0.65 | HTR4 (0.40) | ADORA2BSLC16A1HTT | |
| SCHEMBL5864669 | 0.63 | PDE1B (0.47) | SLC16A1LMNA | |
| SCHEMBL23430530 | 0.61 | ALDH1A1 (0.38) | ADORA2BALDH1A1HTT | |
| SCHEMBL7010765 | 0.61 | SLC16A1 (0.38) | ADORA2BSLC16A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107973-B1 | NOVEL THIENO[2,3-d]PYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION AND USE THEREOF IN THERAPY | ASTRAZENECA AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| US-6300334-B1 | DRUGS FOR TREATMENT OF RESPIRATORY SYSTEM DISORDERS | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |
| EP-1107973-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012514-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |