Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | TNF | P01375 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035239 | 0.80 | KDM4E (0.72) | KDM4EALDH1A1TNIKL3MBTL1SMN1; SMN2 | |
| SCHEMBL15156423 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1TNIKL3MBTL1SMN1; SMN2 | |
| SCHEMBL3166509 | 0.79 | KIT (0.51) | SMN1; SMN2 | |
| SCHEMBL1604864 | 0.76 | KDM4E (0.66) | KDM4EALDH1A1TNIKL3MBTL1SMN1; SMN2 | |
| SCHEMBL11077344 | 0.76 | CA12 (0.56) | L3MBTL1SMN1; SMN2GAALMNAKMT2A | |
| SCHEMBL694950 | 0.75 | RAB9A (0.73) | KDM4EALDH1A1L3MBTL1SMN1; SMN2HRH3 | |
| SCHEMBL16629085 | 0.75 | KDM4E (0.65) | KDM4EALDH1A1TNIKL3MBTL1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL2269036 | 0.75 | ALDH1A1 (0.57) | KDM4EALDH1A1HRH3GAALMNA | |
| SCHEMBL16620534 | 0.75 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2HRH3GAA | |
| SCHEMBL28663251 | 0.74 | RAB9A (0.76) | KDM4EALDH1A1L3MBTL1MCHR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1315726-A1 | 7- OXO PYRIDOPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-04 | — | — | EP | disclosed |
| WO-2002018380-A1 | 7-OXO PYRIDOPYRIMIDINES AS INHIBITORS OF A CELLULAR PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-07 | — | — | WO | disclosed |