Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2267982 | 0.98 | SIGMAR1 (0.57) | ALDH1A1HRH3CYP2D6CYP2C9HIF1A | |
| Trifluoroacetic Acid SCHEMBL2267986 | 0.98 | SIGMAR1 (0.57) | ALDH1A1HRH3CYP2D6CYP2C9HIF1A | |
| Bicarbonate SCHEMBL28225544 | 0.86 | ALDH1A1 (0.64) | ALDH1A1HRH3CYP2D6CYP2C9HIF1A | |
| Acetic Acid SCHEMBL7594626 | 0.84 | ALDH1A1 (0.62) | ALDH1A1HRH3CYP2D6CYP2C9HIF1A | |
| 1-Phenethylpiperidine SCHEMBL14734798 | 0.84 | SIGMAR1 (0.72) | ALDH1A1HRH3SIGMAR1KMT2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL2267366 | 0.84 | KCNJ1 (0.67) | ALDH1A1HRH3HIF1AKDM4ESIGMAR1 | |
| SCHEMBL11141692 | 0.84 | SIGMAR1 (0.77) | ALDH1A1HRH3CYP2D6KDM4ESIGMAR1 | |
| SCHEMBL8327 | 0.84 | SIGMAR1 (0.77) | ALDH1A1HRH3CYP2D6KDM4ESIGMAR1 | |
| SCHEMBL11585348 | 0.84 | SIGMAR1 (0.77) | ALDH1A1HRH3CYP2D6KDM4ESIGMAR1 | |
| SCHEMBL688047 | 0.84 | SIGMAR1 (0.77) | ALDH1A1HRH3CYP2D6KDM4ESIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201657-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-18 | — | — | US | disclosed |
| US-20090275619-A1 | Amide Substituted Indazole and Benzotriazole Derivatives as Poly(ADP-Ribose)Polymerase (PARP) Inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275619-A1 | Amide Substituted Indazole and Benzotriazole Derivatives as Poly(ADP-Ribose)Polymerase (PARP) Inhibitors | PARP1, PARP3, PARP2 | ALDH1A1 325/4885HRH3 1564/4885CYP2D6 3870/4885 |
| US-20110201657-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | PARP1, PARP3, PARP2 | ALDH1A1 325/4885HRH3 1564/4885CYP2D6 3870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.