SCHEMBL7008773

SCHEMBL7008773

N#Cc1c(F)cccc1-n1ccn2c(cc3ccc(OCc4ccccc4)cc32)c1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AS3MT Q9HBK9 3/20 0.41
TDP2 O95551 2/20 0.41
MAOB P27338 7/20 0.40
MAOA P21397 4/20 0.40
PDCD1 Q15116 1/20 0.40
CD274 Q9NZQ7 1/20 0.40
NSD2 O96028 1/20 0.38
CTSV O60911 1/20 0.36
CTSL P07711 1/20 0.36
ALOX5 P09917 1/20 0.36
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA3 P07451 1/20 0.35
CA4 P22748 1/20 0.35
CA6 P23280 1/20 0.35
CA7 P43166 1/20 0.35
MTNR1A P48039 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7008033 0.89 AS3MT (0.41) AS3MTTDP2MAOBMAOAPDCD1
SCHEMBL7009665 0.79 ALOX5 (0.47) MAOBMAOAALOX5MEN1NPC1
SCHEMBL7002364 0.75 NPC1 (0.47) MEN1NPC1KMT2A
SCHEMBL7005823 0.74 ALOX5 (0.41) MAOBMAOANSD2ALOX5MEN1
SCHEMBL7006729 0.74 ALOX5 (0.48) MAOBMAOAALOX5MEN1NPC1
SCHEMBL7006801 0.73 MAPK14 (0.54) MAOBMAOANSD2ALOX5MEN1
SCHEMBL7004499 0.71 MCHR1 (0.47) MAOBMAOANSD2ALOX5MEN1
SCHEMBL7004088 0.70 ALDH1A1 (0.55) MEN1KMT2A
SCHEMBL7003213 0.68 NSD2 (0.50) MAOBMAOANSD2CTSVCTSL
SCHEMBL7001976 0.68 MCHR1 (0.47) MAOBALOX5MEN1NPC1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1200439-B1 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES NOVUSPHARMA SPA (IT) 2003-06-25 EP disclosed