Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMAD3 | P84022 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA4 | P22748 | 2/20 | 0.37 |
| ▸ | CA6 | P23280 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | GNG2 | P59768 | 1/20 | 0.37 |
| ▸ | GNB1 | P62873 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | TPMT | P51580 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4478640 | 0.89 | SMAD3 (0.42) | SMAD3HTTGNG2GNB1ALDH1A1 | |
| SCHEMBL1230563 | 0.81 | SMAD3 (0.44) | SMAD3HTTCA12CA1CA2 | |
| SCHEMBL6026564 | 0.80 | SMAD3 (0.41) | SMAD3HTTPTGS2CA12CA1 | |
| SCHEMBL8207884 | 0.79 | SMAD3 (0.48) | SMAD3GNG2GNB1ALDH1A1THRB | |
| SCHEMBL29401708 | 0.78 | GNG2 (0.50) | SMAD3HTTPTGS2CA12CA1 | |
| SCHEMBL15019692 | 0.78 | GNG2 (0.50) | SMAD3HTTPTGS2CA12CA1 | |
| SCHEMBL17001191 | 0.75 | SMAD3 (0.45) | SMAD3CA12CA1CA2CA7 | |
| SCHEMBL3896904 | 0.74 | PTGS2 (0.36) | SMAD3HTTPTGS2CA12CA1 | |
| SCHEMBL20526344 | 0.73 | SMAD3 (0.41) | SMAD3HTTGNG2GNB1PKM | |
| SCHEMBL29838713 | 0.73 | MEN1 (0.39) | HTTPTGS2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210214391-A1 | Peptide Activating Agent | INTERK PEPTIDE THERAPEUTICS LIMITED (AU) | 2021-07-15 | — | — | US | disclosed |
| US-20120315629-A1 | Cloning and Expression of arNOX Protein Transmembrane 9 Superfamily (TM9SF), Methods and Utility | Nox Technologies ,Inc. (US) | 2012-12-13 | — | — | US | disclosed |
| US-8124725-B2 | PDGF-Rβ binders | GENERAL ELECTRIC COMPANY (US) | 2012-02-28 | — | — | US | disclosed |
| US-20090191124-A1 | PDGF-RBeta BINDERS | GENERAL ELECTRIC COMPANY (US) | 2009-07-30 | — | — | US | disclosed |
| US-20090064350-A1 | DETECTION AND TREATMENT OF DRUG ASSOCIATED ANGIOEDEMA | DEWALD GEORG | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090191124-A1 | PDGF-RBeta BINDERS | PDGFRB, PDGFA, PDGFRA | SMAD3 179/4885HTT 1773/4885PTGS2 3226/4885 |
| US-20210214391-A1 | Peptide Activating Agent | LCK, CD69, VIP | SMAD3 3620/4885HTT 3995/4885PTGS2 4385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.