Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | TPMT | P51580 | 4/20 | 0.44 |
| ▸ | CA5A | P35218 | 3/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA7 | P43166 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | CA6 | P23280 | 2/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15709749 | 0.91 | CA5A (0.52) | POLBHCAR2CA5AAKR1C3AKR1C2 | |
| SCHEMBL9350174 | 0.88 | TPMT (0.55) | TTRTPMTCA5AAKR1C3AKR1C2 | |
| SCHEMBL11762568 | 0.88 | TPMT (0.55) | TTRTPMTCA5AAKR1C3AKR1C2 | |
| SCHEMBL23501889 | 0.88 | TTR (0.56) | POLBHCAR2TTRTPMTCA5A | |
| SCHEMBL475757 | 0.88 | TTR (0.56) | POLBHCAR2TTRTPMTCA5A | |
| SCHEMBL27896747 | 0.85 | TTR (0.54) | POLBHCAR2TTRTPMTCA5A | |
| SCHEMBL343284 | 0.85 | CA5A (0.52) | POLBHCAR2CA5AAKR1C3AKR1C2 | |
| Ethylene SCHEMBL28706399 | 0.83 | TTR (0.52) | POLBHCAR2TTRTPMTCA5A | |
| SCHEMBL8361 | 0.83 | TTR (0.56) | POLBHCAR2TTRTPMTCA5A | |
| SCHEMBL3190842 | 0.83 | POLB (0.44) | POLBHCAR2TTRTPMTCA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104803921-A | Preparation method of benzene-substituted pyrimidine derivative | CHANGSHA SHENCHENG BIOTECHNOLOGY CO LTD | 2015-07-29 | — | — | CN | claimed |
| US-20160002273-A1 | THIENO[3,2-D]PYRIMIDINE-6-CARBOXAMIDES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2016-01-07 | — | — | US | disclosed |
| CN-104803921-A | Preparation method of benzene-substituted pyrimidine derivative | CHANGSHA SHENCHENG BIOTECHNOLOGY CO LTD | 2015-07-29 | — | — | CN | disclosed |
| CN-104803921-A | Preparation method of benzene-substituted pyrimidine derivative | CHANGSHA SHENCHENG BIOTECHNOLOGY CO LTD | 2015-07-29 | — | — | CN | disclosed |
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| CN-1324359-A | Tricyclic carboxamides | SMITHKLINE BEECHAM PLC (GB) | 2001-11-28 | — | — | CN | disclosed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002273-A1 | THIENO[3,2-D]PYRIMIDINE-6-CARBOXAMIDES AND ANALOGUES AS SIRTUIN MODULATORS | SIRT2, SIRT1, SIRT6 | POLB 2535/4885HCAR2 366/4885TTR 3535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.