Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | PRKCI | P41743 | 14/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8185252 | 0.95 | PTGS2 (0.51) | PTGS2PRKCIPRKCZKDM4EMEN1 | |
| SCHEMBL7015745 | 0.86 | PTGS2 (0.53) | PTGS2PRKCIPRKCZKDM4EMEN1 | |
| SCHEMBL8176873 | 0.86 | PRKCI (0.50) | PTGS2PRKCISMN1; SMN2 | |
| SCHEMBL8180415 | 0.86 | PTGS2 (0.63) | PTGS2PRKCIPRKCZKDM4EMEN1 | |
| SCHEMBL8177887 | 0.85 | PRKCI (0.46) | PRKCIMAPTSMN1; SMN2CNR2 | |
| SCHEMBL8172557 | 0.83 | LMNA (0.41) | KDM4EMEN1NPC1MAPTHPGD | |
| SCHEMBL8183436 | 0.83 | LMNA (0.43) | KDM4EMEN1NPC1TP53MAPT | |
| SCHEMBL5780867 | 0.83 | PRKCI (0.66) | PRKCIPRKCZ | |
| Bicarbonate SCHEMBL7016998 | 0.82 | PTPN12 (0.51) | PTGS2PRKCIKDM4EMEN1NPC1 | |
| SCHEMBL8180183 | 0.80 | ALDH1A1 (0.43) | KDM4ENPC1GAAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |