Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.52 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015626 | 0.87 | HTT (0.67) | SMN1; SMN2TSHRMAOAMAOBALDH1A1 | |
| SCHEMBL7017271 | 0.86 | TSHR (0.59) | SMN1; SMN2TSHRMAOAMAOBALDH1A1 | |
| SCHEMBL7016485 | 0.84 | ALDH1A1 (0.60) | SMN1; SMN2TSHRMAOAMAOBALDH1A1 | |
| SCHEMBL8646592 | 0.83 | TSHR (0.47) | SMN1; SMN2TSHRMAOAMAOBALDH1A1 | |
| SCHEMBL16028240 | 0.81 | TRPC5 (0.76) | SMN1; SMN2TSHRMAOAMAOBALDH1A1 | |
| SCHEMBL31575394 | 0.80 | ALDH1A1 (0.71) | SMN1; SMN2ALDH1A1POLBMAPTMAPK1 | |
| SCHEMBL16029826 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2TSHRMAOAMAOBALDH1A1 | |
| SCHEMBL16029209 | 0.78 | HTT (0.78) | SMN1; SMN2TSHRMAOAMAOBALDH1A1 | |
| SCHEMBL16079574 | 0.77 | TRPC4 (0.70) | SMN1; SMN2TSHRALDH1A1POLBMAPT | |
| SCHEMBL16079509 | 0.77 | ALDH1A1 (0.71) | SMN1; SMN2TSHRMAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |