SCHEMBL7016446

SCHEMBL7016446

O=C(NCCCCC(=O)N1CCC2OCC(=O)C21)c1ccc(-c2ccccc2)nc1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.48
CTSS P25774 4/20 0.44
CTSV O60911 3/20 0.44
CTSL P07711 3/20 0.44
HPGDS O60760 2/20 0.43
DPP4 P27487 2/20 0.43
CTSK P43235 3/20 0.43
USP30 Q70CQ3 1/20 0.42
HDAC6 Q9UBN7 1/20 0.40
BAZ2B Q9UIF8 1/20 0.39
OPRM1 P35372 1/20 0.38
OPRD1 P41143 1/20 0.38
OPRK1 P41145 1/20 0.38
NAMPT P43490 1/20 0.37
MCHR1 Q99705 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7020985 0.81 CTSK (0.46) CTSSCTSVCTSLDPP4CTSK
SCHEMBL7021109 0.80 CTSK (0.41) CTSSCTSVCTSLDPP4CTSK
SCHEMBL7024341 0.79 NAMPT (0.48) HDAC1CTSSCTSVCTSLDPP4
SCHEMBL7019711 0.79 LMNA (0.52) HDAC1CTSSCTSVCTSLDPP4
SCHEMBL4452940 0.79 CTSS (0.59) CTSSCTSVCTSLHPGDSCTSK
SCHEMBL4452987 0.78 CTSK (0.68) CTSSCTSVCTSLCTSK
SCHEMBL4459296 0.78 CTSS (0.71) CTSSCTSVCTSLHPGDSCTSK
SCHEMBL4444451 0.77 CTSS (0.58) CTSSCTSVCTSLHPGDSCTSK
SCHEMBL7017128 0.77 CTSK (0.44) CTSSCTSVCTSLDPP4CTSK
SCHEMBL7023221 0.77 HDAC3 (0.41) HDAC1CTSSCTSVCTSLDPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1362052-A1 INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES Amura Therapeutics Limited (GB) 2003-11-19 EP disclosed
WO-2002057270-A1 INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES AMURA THERAPEUTICS LIMITED (GB) 2002-07-25 WO disclosed