Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.44 |
| ▸ | DPP4 | P27487 | 10/20 | 0.42 |
| ▸ | CTSS | P25774 | 4/20 | 0.42 |
| ▸ | CTSV | O60911 | 3/20 | 0.42 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015308 | 0.85 | CTSK (0.46) | CTSKCTSSCTSVCTSLKMT2A | |
| SCHEMBL7020985 | 0.85 | CTSK (0.46) | CTSKDPP4CTSSCTSVCTSL | |
| SCHEMBL7024341 | 0.83 | NAMPT (0.48) | CTSKDPP4CTSSCTSVCTSL | |
| SCHEMBL7016550 | 0.80 | CTSK (0.41) | CTSKDPP4CTSSCTSVCTSL | |
| SCHEMBL7019711 | 0.79 | LMNA (0.52) | CTSKDPP4CTSSCTSVCTSL | |
| SCHEMBL7021109 | 0.78 | CTSK (0.41) | CTSKDPP4CTSSCTSVCTSL | |
| SCHEMBL4451968 | 0.77 | CTSS (0.69) | CTSKCTSSCTSVCTSLKMT2A | |
| SCHEMBL4456121 | 0.77 | CTSK (0.74) | CTSKCTSSCTSVCTSL | |
| SCHEMBL7016446 | 0.77 | HDAC1 (0.48) | CTSKDPP4CTSSCTSVCTSL | |
| SCHEMBL4452934 | 0.76 | CTSK (0.60) | CTSKCTSSCTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |