Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013194 | 0.77 | LMNA (0.33) | SMN1; SMN2RAB9ANPC1LMNACYP1A2 | |
| SCHEMBL2544338 | 0.77 | RAB9A (0.55) | SMN1; SMN2RAB9ANPC1LMNACYP1A2 | |
| SCHEMBL17738012 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9ANPC1LMNACYP1A2 | |
| SCHEMBL11272569 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9ANPC1LMNACYP1A2 | |
| SCHEMBL3847199 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9ANPC1LMNACYP1A2 | |
| SCHEMBL1627207 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9ANPC1LMNACYP1A2 | |
| SCHEMBL7016296 | 0.74 | SMN1; SMN2 (0.33) | SMN1; SMN2RAB9ANPC1LMNACYP1A2 | |
| SCHEMBL9726722 | 0.73 | RAB9A (0.46) | SMN1; SMN2RAB9ANPC1LMNACYP1A2 | |
| SCHEMBL21511152 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ANPC1LMNACYP1A2 | |
| SCHEMBL3845405 | 0.69 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9ANPC1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |