Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15866724 | 0.86 | ACHE (0.49) | CNR2NPC1L1 | |
| SCHEMBL4398812 | 0.84 | PPARG (0.45) | KMT2APARP1PARP14PARP10 | |
| SCHEMBL14879910 | 0.83 | L3MBTL3 (0.44) | CNR2NAMPTPARP14PARP10 | |
| SCHEMBL18652719 | 0.82 | NAMPT (0.42) | CNR2NAMPTKMT2APARP1PARP14 | |
| SCHEMBL12801917 | 0.81 | MGLL (0.50) | — | |
| SCHEMBL15788475 | 0.81 | ALDH1A1 (0.46) | CNR2NAMPTALDH1A1TP53 | |
| SCHEMBL14898172 | 0.81 | MGLL (0.45) | CNR2NAMPTPARP14PARP10 | |
| SCHEMBL14885438 | 0.80 | NAMPT (0.43) | CNR2NAMPTKMT2ALMNATP53 | |
| SCHEMBL1381265 | 0.79 | TPSAB1 (0.58) | PARP1PARP14PARP10 | |
| SCHEMBL1668933 | 0.79 | PARP14 (0.44) | NAMPTALDH1A1KMT2ALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296972-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001090101-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-11-29 | — | — | WO | disclosed |