Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | FABP6 | P51161 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019117 | 0.82 | LMNA (0.43) | TRPA1LMNAMAPK1MMP13RAB9A | |
| SCHEMBL7012213 | 0.80 | LMNA (0.48) | TRPA1LMNAMAPK1KMT2ASCD | |
| SCHEMBL7011737 | 0.77 | LMNA (0.48) | TRPA1LMNAMAPK1KMT2ASCD | |
| SCHEMBL7010376 | 0.76 | LMNA (0.45) | TRPA1LMNAMAPK1KMT2AVNN1 | |
| SCHEMBL7012844 | 0.76 | HDAC1 (0.47) | LMNAMMP13KMT2AVNN1SMN1; SMN2 | |
| SCHEMBL7011108 | 0.76 | LMNA (0.84) | LMNAMAPK1SMN1; SMN2HTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL7019827 | 0.75 | LMNA (0.82) | LMNAMAPK1SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL7012224 | 0.75 | HTT (0.43) | LMNAMAPK1KMT2AVNN1SMN1; SMN2 | |
| SCHEMBL7012004 | 0.74 | LMNA (0.40) | LMNAKMT2AVNN1SMN1; SMN2HTT | |
| SCHEMBL7018390 | 0.74 | LMNA (0.69) | TRPA1LMNAMAPK1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |