Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017977 | 0.82 | TRPA1 (0.50) | LMNAMAPK1SMN1; SMN2KCNH2VNN1 | |
| SCHEMBL7012844 | 0.81 | HDAC1 (0.47) | LMNASMN1; SMN2VNN1HTTKMT2A | |
| SCHEMBL7011737 | 0.80 | LMNA (0.48) | LMNAMAPK1SMN1; SMN2VNN1YTHDC1 | |
| SCHEMBL7011568 | 0.80 | HPGD (0.44) | LMNASMN1; SMN2HTTKMT2AMEN1 | |
| SCHEMBL7012213 | 0.77 | LMNA (0.48) | LMNAMAPK1SMN1; SMN2VNN1YTHDC1 | |
| SCHEMBL7010653 | 0.77 | PKM (0.45) | LMNASMN1; SMN2VNN1HTTTSHR | |
| SCHEMBL7012335 | 0.76 | LMNA (0.45) | LMNAMAPK1SMN1; SMN2VNN1YTHDC1 | |
| SCHEMBL8642267 | 0.76 | LMNA (0.55) | LMNAMAPK1SMN1; SMN2HTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL8648397 | 0.75 | LMNA (0.54) | LMNAMAPK1SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL7013283 | 0.75 | HTT (0.40) | LMNASMN1; SMN2VNN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |