Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.39 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012335 | 0.92 | LMNA (0.45) | LMNAMAPK1SMN1; SMN2VNN1NR3C1 | |
| SCHEMBL7012213 | 0.87 | LMNA (0.48) | LMNAMAPK1SMN1; SMN2VNN1TRPA1 | |
| SCHEMBL7011737 | 0.83 | LMNA (0.48) | LMNAMAPK1SMN1; SMN2VNN1TRPA1 | |
| SCHEMBL7017977 | 0.76 | TRPA1 (0.50) | LMNAMAPK1SMN1; SMN2VNN1TRPA1 | |
| SCHEMBL7019117 | 0.74 | LMNA (0.43) | LMNAMAPK1SMN1; SMN2VNN1NR3C1 | |
| SCHEMBL7011613 | 0.73 | MAPK1 (0.43) | LMNAMAPK1SMN1; SMN2VNN1NR3C1 | |
| SCHEMBL7021991 | 0.73 | HDAC1 (0.42) | LMNAMAPK1SMN1; SMN2VNN1HDAC1 | |
| SCHEMBL8642267 | 0.73 | LMNA (0.55) | LMNAMAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL7011108 | 0.73 | LMNA (0.84) | LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL7015484 | 0.73 | HDAC6 (0.44) | LMNAMAPK1SMN1; SMN2VNN1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |