Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 4/20 | 0.34 |
| ▸ | MAOB | P27338 | 4/20 | 0.34 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018866 | 1.00 | TDP1 (0.36) | TDP1NPC1RAB9AVCPMAOA | |
| SCHEMBL7573265 | 0.92 | VCP (0.40) | TDP1NPC1RAB9AVCPMAOA | |
| SCHEMBL7573261 | 0.92 | VCP (0.40) | TDP1NPC1RAB9AVCPMAOA | |
| SCHEMBL110123 | 0.63 | ALDH1A1 (0.60) | TDP1GAAKDM4EALDH1A1CA2 | |
| SCHEMBL3754587 | 0.63 | NPC1 (0.43) | TDP1NPC1RAB9AVCPMAOA | |
| SCHEMBL3754585 | 0.63 | NPC1 (0.43) | TDP1NPC1RAB9AVCPMAOA | |
| SCHEMBL2394174 | 0.62 | DPEP1 (0.49) | TDP1NPC1RAB9AVCPMAOA | |
| SCHEMBL7576321 | 0.62 | IDO1 (0.50) | TDP1NPC1RAB9AVCPMAOA | |
| SCHEMBL1907796 | 0.62 | DPEP1 (0.49) | TDP1NPC1RAB9AVCPMAOA | |
| SCHEMBL7583346 | 0.62 | NPC1 (0.40) | TDP1NPC1RAB9AVCPMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307453-A2 | DIHYDRONAPHTHYRIDINE- AND DIHYDROPYRROLOPYRIDINE-DERIVATED COMPOUNDS AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002010164-A2 | DIHYDRONAPHTHYRIDINE- AND DIHYDROPYRROLOPYRIDINE-DERIVATED COMPOUNDS AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-02-07 | — | — | WO | disclosed |