Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6475863 | 0.86 | L3MBTL1 (0.57) | RAB9ATSHRSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL6477711 | 0.86 | SIGMAR1 (0.56) | RAB9ATSHRSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL6485660 | 0.84 | RAB9A (0.61) | RAB9ATSHRSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL6485663 | 0.84 | RAB9A (0.61) | RAB9ATSHRSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL6483700 | 0.84 | KDM4E (0.43) | RAB9ATSHRSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL6477010 | 0.83 | TSHR (0.66) | RAB9ATSHRSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL6476905 | 0.79 | TSHR (0.62) | RAB9ATSHRSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL6487303 | 0.78 | RAB9A (0.70) | RAB9ATSHRSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL6477456 | 0.77 | SIGMAR1 (0.55) | RAB9ATSHRSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL9534830 | 0.75 | HPGD (0.58) | RAB9ATSHRSMN1; SMN2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252150-B1 | HETEROCYCLIC DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2003-06-04 | — | — | EP | claimed |
| EP-1252150-A1 | NOVEL HETEROCYCLIC DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier (FR) | 2002-10-30 | — | — | EP | claimed |
| WO-2001057002-A1 | NOVEL HETEROCYCLIC DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2001-08-09 | — | — | WO | claimed |
| EP-1252150-B1 | HETEROCYCLIC DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2003-06-04 | — | — | EP | disclosed |
| EP-1252150-A1 | NOVEL HETEROCYCLIC DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier (FR) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057002-A1 | NOVEL HETEROCYCLIC DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2001-08-09 | — | — | WO | disclosed |