Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.64 |
| ▸ | HTR1D | P28221 | 4/20 | 0.64 |
| ▸ | HTR1B | P28222 | 4/20 | 0.64 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.55 |
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | NQO2 | P16083 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7024310 | 0.89 | MTNR1A (0.70) | HTR1AHTR1DHTR1BMTNR1AKMT2A | |
| SCHEMBL7099794 | 0.83 | MTNR1A (0.88) | HTR1AMTNR1AKMT2AMEN1MTNR1B | |
| SCHEMBL7964472 | 0.81 | MTNR1A (0.72) | MTNR1AMTNR1BNQO2HTR2BTRPV1 | |
| SCHEMBL18222539 | 0.79 | TRPM8 (0.75) | HTR1DMTNR1AKMT2AMEN1MTNR1B | |
| SCHEMBL7024455 | 0.79 | HTR1A (0.61) | HTR1AHTR1DHTR1BKMT2AMEN1 | |
| SCHEMBL18239782 | 0.79 | MTNR1A (0.65) | HTR1AHTR1DHTR1BMTNR1AKMT2A | |
| SCHEMBL9272896 | 0.78 | HTR1D (1.00) | HTR1AHTR1DHTR1BMTNR1AKMT2A | |
| SCHEMBL7100086 | 0.77 | SPR (0.76) | MTNR1AKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL8064758 | 0.77 | MTNR1A (0.63) | MTNR1AMTNR1BNQO2HTR2BTRPV1 | |
| SCHEMBL9278912 | 0.76 | HTR1D (1.00) | HTR1AHTR1DHTR1BKMT2AMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057826-B1 | Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-04-16 | — | — | EP | disclosed |
| US-6310074-B1 | TREATING MELATONINERGIC DISORDERS | ADIR ET COMPAGNIE (FR) | 2001-10-30 | — | — | US | disclosed |
| EP-1057826-A1 | Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-12-06 | — | — | EP | disclosed |