SCHEMBL7024910

SCHEMBL7024910

CCc1nsc(S(=O)(=O)c2ccc(C)cc2)n1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.46
MAPT P10636 2/20 0.44
HTT P42858 1/20 0.44
HSD17B10 Q99714 1/20 0.44
RXFP1 Q9HBX9 2/20 0.41
ALDH1A1 P00352 3/20 0.41
MEN1 O00255 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
KMT2A Q03164 1/20 0.40
POLB P06746 2/20 0.40
USP2 O75604 1/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7026099 0.84 RECQL (0.44) GAAMAPTHTTHSD17B10RXFP1
SCHEMBL14755439 0.81 CYP3A4 (0.44) GAAMAPTHTTHSD17B10ALDH1A1
SCHEMBL14755599 0.81 GAA (0.48) GAAMAPTHTTHSD17B10RXFP1
SCHEMBL799810 0.79 BCHE (0.47) MAPTHTTHSD17B10RXFP1ALDH1A1
SCHEMBL1568853 0.78 CNR2 (0.47) MAPTHTTHSD17B10ALDH1A1MEN1
SCHEMBL1081206 0.77 ALDH1A1 (0.49) GAAMAPTHTTHSD17B10ALDH1A1
SCHEMBL8075141 0.77 ADORA3 (0.50) GAAMAPTHTTRXFP1ALDH1A1
SCHEMBL14755486 0.76 PTGS2 (0.49) GAATSHR
SCHEMBL1570964 0.76 HTR6 (0.44) MAPTALDH1A1
SCHEMBL8443790 0.75 GAA (0.46) GAAMAPTHTTHSD17B10ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0749433-B1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY SYNGENTA LTD (GB) 2003-05-07 EP disclosed
US-5952359-A NEMATICIDES, INSECTICIDES AND MITICIDES; 1,1-DIFLUORO-3-(THIAZOLYL OR ISOTHIAZOYL-THIO (OR SULFINYL OR SULFONYL)-PROP-1-ENE DERIVATIVES ZENECA LIMITED (GB) 1999-09-14 US disclosed
US-5912243-A NOVEL COMPOUNDS FOR CONTROLLING NEMATODES, INSECT OR ACARID PESTS ZENECA LIMITED (GB) 1999-06-15 US disclosed
US-5705516-A NEMATOCIDES, INSECTICIDES, ACARICIDES ZENECA LIMITED (GB) 1998-01-06 US disclosed
CN-1143958-A (4,4-difluorobut-3-enylthio-)-substituted heterocyclic or carbocyclic ring compounds ZENECA LTD (GB) 1997-02-26 CN disclosed
EP-0749433-A1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY ZENECA LIMITED (GB) 1996-12-27 EP disclosed
WO-1995024403-A1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY ZENECA LIMITED (GB) 1995-09-14 WO disclosed