Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GRK6 | P43250 | 1/20 | 0.50 |
| ▸ | XPO1 | O14980 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | CPT1A | P50416 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033927 | 0.84 | LMNA (0.67) | LMNAHDAC8NR1H2NR1H3HDAC6 | |
| SCHEMBL22950683 | 0.78 | RAB9A (0.46) | LMNAGRK6PTGDR2NR1H2PTGDR | |
| SCHEMBL4789113 | 0.75 | ROCK2 (0.55) | LMNA | |
| SCHEMBL26478315 | 0.74 | GRK6 (0.55) | KDM4ESMN1; SMN2GRK6XPO1NR1H2 | |
| SCHEMBL27795015 | 0.72 | HPGDS (0.52) | KDM4ESMN1; SMN2PTGDR2PDE4BPDE4D | |
| SCHEMBL15117051 | 0.72 | NPC1 (0.57) | SMN1; SMN2LMNAGRK6NR1H2NR1H3 | |
| SCHEMBL14736425 | 0.72 | LMNA (0.63) | LMNAHDAC8NR1H2NR1H3HDAC6 | |
| SCHEMBL7597446 | 0.70 | LMNA (0.51) | KDM4ESMN1; SMN2LMNANR1H2NR1H3 | |
| SCHEMBL13802492 | 0.69 | GRIN2D (0.55) | KDM4ESMN1; SMN2LMNA | |
| SCHEMBL13913103 | 0.69 | NR1H2 (0.53) | SMN1; SMN2LMNAHDAC8NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368342-A2 | BENZIMIDAZOLE AND PYRIDYLIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | NEUROGEN CORPORATION (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002050062-A2 | BENZIMIDAZOLE AND PYRIDYLIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | NEUROGEN CORPORATION (US) | 2002-06-27 | — | — | WO | disclosed |