Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 12/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7027498 | 0.96 | MMP3 (0.47) | F10MMP3CA1CA2PRSS1 | |
| SCHEMBL7024688 | 0.86 | F10 (0.43) | F10PRSS1F2SCN9A | |
| SCHEMBL7025525 | 0.81 | F10 (0.44) | F10PRSS1F2SCN9A | |
| SCHEMBL7030335 | 0.79 | EPHX1 (0.60) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL2476366 | 0.78 | CA2 (0.50) | CA1CA2MMP9MMP8MMP13 | |
| SCHEMBL1945087 | 0.77 | EPHX1 (0.54) | MMP9MMP8MMP13 | |
| SCHEMBL9395046 | 0.77 | MMP9 (0.56) | CA1CA2MMP9MMP8MMP13 | |
| SCHEMBL675017 | 0.77 | MMP9 (0.56) | CA1CA2MMP9MMP8MMP13 | |
| SCHEMBL7019484 | 0.77 | F10 (0.47) | F10CA1CA2PRSS1F2 | |
| SCHEMBL21359023 | 0.76 | EPHX1 (0.53) | MMP3MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309549-A1 | ACETAMIDE DERIVATIVES AND THE USE THEREOF AS INHIBITORS OF COAGULATION FACTORS XA AND VIIA | MERCK PATENT GmbH (DE) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002010127-A1 | ACETAMIDE DERIVATIVES AND THE USE THEREOF AS INHIBITORS OF COAGULATION FACTORS XA AND VIIA | MERCK PATENT GMBH (DE) | 2002-02-07 | — | — | WO | disclosed |