Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.56 |
| ▸ | CTSK | P43235 | 3/20 | 0.56 |
| ▸ | CTSL | P07711 | 2/20 | 0.56 |
| ▸ | REN | P00797 | 3/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 12/20 | 0.43 |
| ▸ | MMP1 | P03956 | 10/20 | 0.43 |
| ▸ | MMP3 | P08254 | 10/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5934865 | 1.00 | CTSS (0.56) | CTSSCTSKCTSLRENCTSB | |
| SCHEMBL5934662 | 0.85 | CTSS (0.57) | CTSSCTSKCTSLRENCTSB | |
| SCHEMBL7033255 | 0.85 | CTSS (0.57) | CTSSCTSKCTSLRENCTSB | |
| SCHEMBL5934874 | 0.81 | CTSK (0.57) | CTSSCTSKCTSLRENCTSB | |
| SCHEMBL7471828 | 0.80 | CTSK (0.61) | CTSSCTSKCTSLCTSB | |
| SCHEMBL7029711 | 0.76 | LTA4H (0.60) | RENMMP2MMP1MMP3 | |
| SCHEMBL5934957 | 0.76 | CTSK (0.51) | CTSSCTSKCTSLCTSBMMP2 | |
| SCHEMBL5934599 | 0.76 | CTSK (0.51) | CTSSCTSKCTSLCTSBMMP2 | |
| SCHEMBL10889192 | 0.72 | CTSL (0.55) | CTSSCTSKCTSL | |
| SCHEMBL10895418 | 0.72 | CTSL (0.55) | CTSSCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929571-B1 | 4-SUBSTITUTED-3-(2-AMINO-2-CYCLOALKYL METHYL)-ACETAMIDO AZETIDIN-2-ONE DERIVATIVES AS CYSTEINE PROTEINASE REGULATORS | NAEJA PHARMACEUTICAL INC (CA) | 2003-02-26 | — | — | EP | claimed |
| EP-0929571-B1 | 4-SUBSTITUTED-3-(2-AMINO-2-CYCLOALKYL METHYL)-ACETAMIDO AZETIDIN-2-ONE DERIVATIVES AS CYSTEINE PROTEINASE REGULATORS | NAEJA PHARMACEUTICAL INC (CA) | 2003-02-26 | — | — | EP | disclosed |
| US-5916887-A | TREATMENT OF ARTHRITIS, INFLAMMATION, ALZHEIMER'S DISEASE | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 1999-06-29 | — | — | US | disclosed |