Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11365473 | 0.85 | KCNH2 (0.47) | KCNH2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL11544580 | 0.82 | L3MBTL1 (0.45) | MAPTKDM4EADAMTS4CA12CA9 | |
| SCHEMBL4801386 | 0.81 | NQO1 (0.49) | RAB9ANPC1MAPTKDM4ECYP2C19 | |
| SCHEMBL11542270 | 0.80 | MAPT (0.54) | KCNH2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL3978000 | 0.80 | KCNH2 (0.43) | KCNH2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL11543780 | 0.79 | MTNR1A (0.46) | RAB9ANPC1KDM4EKMT2AMEN1 | |
| SCHEMBL307859 | 0.79 | CA12 (0.60) | KDM4ECYP2C19CA12CA9CYP2C9 | |
| SCHEMBL11373064 | 0.79 | MAPT (0.43) | MAPTKDM4ECYP2C9ALDH1A1SLC22A12 | |
| SCHEMBL11542872 | 0.79 | RAB9A (0.46) | RAB9ANPC1MAPTKDM4ERXFP1 | |
| SCHEMBL2256874 | 0.78 | KDM4E (0.46) | KCNH2RAB9ANPC1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703910-B1 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | ARYX THERAPEUTICS (US) | 1998-01-07 | — | — | EP | claimed |
| US-4172145-A | ANALGESICS, ANTIPYRETICS | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1979-10-23 | — | — | US | claimed |
| WO-2002038557-A9 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | ARYX THERAPEUTICS (US) | 2003-09-18 | — | — | WO | disclosed |
| EP-1322630-A2 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | Aryx Therapeutics (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002038557-A2 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | ARYX THERAPEUTICS (US) | 2002-05-16 | — | — | WO | disclosed |
| US-6130240-A | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use | ARYX THERAPEUTICS, INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5849788-A | Compound for treatment of cardiac arphythmia, synthesis, and methods of use | ARYX THERAPEUTICS (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0703910-A1 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | Advanced Therapies, Inc. (US) | 1996-04-03 | — | — | EP | disclosed |
| US-5440054-A | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use | ADVANCED THERAPIES, INC. (US) | 1995-08-08 | — | — | US | disclosed |
| WO-1994029289-A1 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | ADVANCED THERAPIES, INC. (US) | 1994-12-22 | — | — | WO | disclosed |
| US-5364880-A | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use | ADVANCED THERAPIES, INC. (US) | 1994-11-15 | — | — | US | disclosed |
| US-4172145-A | ANALGESICS, ANTIPYRETICS | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1979-10-23 | — | — | US | disclosed |
| US-4167638-A | Process for production of 8-NHR quinolines | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1979-09-11 | — | — | US | disclosed |
| US-4126625-A | ANTIPHLOGISTIC, ANALGESIC | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1978-11-21 | — | — | US | disclosed |