Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 6/20 | 0.44 |
| ▸ | FDPS | P14324 | 5/20 | 0.42 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GSTK1 | Q9Y2Q3 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.39 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011486 | 0.86 | FDPS (0.56) | FOLH1FDPSGGPS1LMNAGSTK1 | |
| SCHEMBL328880 | 0.84 | FDPS (0.57) | FOLH1FDPSGGPS1LMNAGSTK1 | |
| SCHEMBL21611867 | 0.80 | FOLH1 (0.59) | FOLH1FDPSGGPS1LMNATSHR | |
| SCHEMBL7030259 | 0.76 | FDPS (0.45) | FDPS | |
| SCHEMBL11396532 | 0.71 | FOLH1 (0.73) | FOLH1LMNAGSTK1TSHRNFKB1 | |
| SCHEMBL1850194 | 0.71 | FOLH1 (0.60) | FOLH1FDPSLMNATSHRNAALAD2 | |
| Adipic Acid SCHEMBL4637028 | 0.70 | LMNA (0.73) | FOLH1LMNATSHRNFKB1PMP22 | |
| SCHEMBL20699855 | 0.70 | FDPS (0.75) | FDPS | |
| Phosphoric Acid SCHEMBL28968052 | 0.68 | KDM4C (0.53) | FOLH1LMNAGSTK1TSHRNFKB1 | |
| SCHEMBL10863085 | 0.67 | FDPS (0.76) | FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131327-B1 | PROSTAGLANDIN CONJUGATES FOR TREATING OR PREVENTING BONE DISEASES | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | disclosed |
| EP-1131327-A1 | PROSTAGLANDIN CONJUGATES FOR TREATING OR PREVENTING BONE DISEASE | Merck Frosst Canada & Co. (CA) | 2001-09-12 | — | — | EP | disclosed |
| US-6121253-A | BONE GROWTH-ENHANCING PROSTAGLANDIN DERIVATIVE CONTAINING BISPHOSPHONATE GROUPS TO INHIBIT BONE RESORPTION; DRUG DELIVERY, SIDE EFFECT REDUCTION, OSTEOPOROSIS | MERCK FROSST CANADA & CO. (CA) | 2000-09-19 | — | — | US | disclosed |
| WO-2000031084-A1 | PROSTAGLANDIN CONJUGATES FOR TREATING OR PREVENTING BONE DISEASE | MERCK FROSST CANADA & CO. (CA) | 2000-06-02 | — | — | WO | disclosed |