Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7520146 | 0.79 | LMNA (0.55) | LMNAHTTTHRBMCL1KDM4E | |
| SCHEMBL23861573 | 0.76 | THRB (0.47) | LMNAHTTTHRBMCL1KDM4E | |
| SCHEMBL9861935 | 0.75 | CA2 (0.42) | LMNAHTTMCL1KDM4EMEN1 | |
| SCHEMBL6566550 | 0.74 | IDO1 (0.59) | THRBKDM4EMEN1MAPTKMT2A | |
| SCHEMBL23861546 | 0.73 | LMNA (0.48) | LMNAHTTTHRBMCL1KDM4E | |
| SCHEMBL29655573 | 0.72 | LMNA (0.62) | LMNAHTTTHRBMCL1KDM4E | |
| SCHEMBL3195164 | 0.72 | LMNA (0.62) | LMNAHTTTHRBMCL1KDM4E | |
| SCHEMBL9861488 | 0.72 | HTT (0.57) | LMNAHTTMCL1KDM4EMEN1 | |
| SCHEMBL5372557 | 0.72 | HSD17B1 (0.42) | KDM4EMEN1MAPTKMT2ATRPM4 | |
| SCHEMBL30226978 | 0.71 | LMNA (0.56) | LMNAHTTTHRBMCL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226134-B1 | NAPHTHOPYRANS HAVING A PERFLUOROALKYL SUBSTITUENT IN POSITION 5, PREPARATION AND COMPOSITIONS CONTAINING THEM | CORNING SA (FR) | 2003-03-05 | — | — | EP | claimed |
| EP-1226134-A2 | NAPHTHOPYRANS HAVING A PERFLUOROALKYL SUBSTITUENT IN POSITION 5, PREPARATION AND COMPOSITIONS AND MATRICES CONTAINING THEM | Corning S.A. (FR) | 2002-07-31 | — | — | EP | claimed |
| WO-2001036424-A2 | NAPHTHOPYRANS HAVING A PERFLUOROALKYL SUBSTITUENT IN POSITION 5, PREPARATION AND COMPOSITIONS AND MATRICES CONTAINING THEM | CORNING S.A. (FR) | 2001-05-25 | — | — | WO | claimed |
| EP-1226134-B1 | NAPHTHOPYRANS HAVING A PERFLUOROALKYL SUBSTITUENT IN POSITION 5, PREPARATION AND COMPOSITIONS CONTAINING THEM | CORNING SA (FR) | 2003-03-05 | — | — | EP | disclosed |
| CN-1387524-A | Naphthopyrans with perfluoroalkyl substituents in the 5-position, process for their preparation and compositions and matrices containing them | CORNING SA (FR) | 2002-12-25 | — | — | CN | disclosed |
| EP-1226134-A2 | NAPHTHOPYRANS HAVING A PERFLUOROALKYL SUBSTITUENT IN POSITION 5, PREPARATION AND COMPOSITIONS AND MATRICES CONTAINING THEM | Corning S.A. (FR) | 2002-07-31 | — | — | EP | disclosed |
| US-6398987-B1 | PHOTOCHROMIC; STRONG COLORABILITY; GREY; BROWN; RAPID DISCOLORATION KINETICS; CONTACT LENSES; SOLAR PROTECTION GLASSES; CAMERA OPTICS | CORNING S.A. (FR) | 2002-06-04 | — | — | US | disclosed |
| WO-2001036424-A2 | NAPHTHOPYRANS HAVING A PERFLUOROALKYL SUBSTITUENT IN POSITION 5, PREPARATION AND COMPOSITIONS AND MATRICES CONTAINING THEM | CORNING S.A. (FR) | 2001-05-25 | — | — | WO | disclosed |