SCHEMBL70334

SCHEMBL70334

Oc1cc(Cl)c(Cl)cc1O

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 10/20 0.73
TSHR P16473 7/20 0.73
HPGD P15428 6/20 0.73
CYP3A4 P08684 5/20 0.56
HSP90AA1 P07900 1/20 0.56
ALDH1A1 P00352 5/20 0.53
TDP1 Q9NUW8 1/20 0.53
ALOX15 P16050 3/20 0.46
ALOX12 P18054 2/20 0.46
CRHBP P24387 1/20 0.44
CRHR2 Q13324 1/20 0.44
TTR P02766 1/20 0.44
CASP1 P29466 1/20 0.44
RECQL P46063 1/20 0.44
TP53 P04637 1/20 0.44
MAPK1 P28482 3/20 0.41
AHR P35869 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29402084 1.00 HSD17B10 (0.73) HSD17B10TSHRHPGDCYP3A4HSP90AA1
Triclofenol SCHEMBL29387498 0.85 HSD17B10 (1.00) HSD17B10TSHRHPGDCYP3A4HSP90AA1
Triclofenol SCHEMBL1338 0.85 HSD17B10 (1.00) HSD17B10TSHRHPGDCYP3A4HSP90AA1
SCHEMBL592892 0.85 HSD17B10 (0.75) HSD17B10TSHRHPGDCYP3A4HSP90AA1
SCHEMBL48305 0.83 HSD17B10 (0.86) HSD17B10TSHRHPGDCYP3A4HSP90AA1
Triclofenol SCHEMBL2813598 0.82 HSD17B10 (0.93) HSD17B10TSHRHPGDCYP3A4HSP90AA1
SCHEMBL10825844 0.77 HSD17B10 (0.55) HSD17B10TSHRHPGDCYP3A4HSP90AA1
SCHEMBL2662863 0.77 LMNA (0.60) HSD17B10TSHRHPGDCYP3A4HSP90AA1
SCHEMBL15149919 0.77 HSD17B10 (0.48) HSD17B10TSHRHPGDCYP3A4HSP90AA1
SCHEMBL5785240 0.77 HSD17B10 (0.55) HSD17B10TSHRHPGDCYP3A4HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 179 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117402494-A Complex high-strength polyarylene sulfide based composite material and preparation and application thereof 新凝合科技(成都)有限公司 2024-01-16 CN claimed
CN-115651203-B Supramolecular crystal framework material based on BN coordination bond and preparation method and application thereof 浙江大学杭州国际科创中心 2023-09-08 CN claimed
US-11673997-B2 Work time to walk-on time ratio by adding a phenolic catalyst to polyaspartic flooring formulations COVESTRO LLC (US) 2023-06-13 US claimed
CN-115651203-A Supermolecular crystal framework material based on BN coordination bond and preparation method and application thereof 浙江大学杭州国际科创中心 2023-01-31 CN claimed
EP-4004076-A1 IMPROVED WORK TIME TO WALK-ON TIME RATIO BY ADDING A PHENOLIC CATALYST TO POLYASPARTIC FLOORING FORMULATIONS Covestro LLC (US) 2022-06-01 EP claimed
CN-114144454-A Improved operating time to open-run time ratio by adding phenolic catalysts to polyaspartic flooring formulations 科思创有限公司 2022-03-04 CN claimed
US-20210032407-A1 WORK TIME TO WALK-ON TIME RATIO BY ADDING A PHENOLIC CATALYST TO POLYASPARTIC FLOORING FORMULATIONS COVESTRO LLC 2021-02-04 US claimed
WO-2021021801-A1 IMPROVED WORK TIME TO WALK-ON TIME RATIO BY ADDING A PHENOLIC CATALYST TO POLYASPARTIC FLOORING FORMULATIONS COVESTRO LLC (US) 2021-02-04 WO claimed
US-20200205541-A1 METHOD FOR STRAIGHTENING KERATINOUS FIBERS USING HEATING MEANS AND AN AROMATIC COMPOUND L'OREAL (FR) 2020-07-02 US claimed
CN-111171085-A Rhamnose donor protected by orthocarbonate, and preparation method and application thereof 山东大学 2020-05-19 CN claimed
US-20130298933-A1 METHOD FOR STRAIGHTENING KERATINOUS FIBERS USING HEATING MEANS AND AN AROMATIC COMPOUND L'OREAL (FR) 2013-11-14 US claimed
CN-103224608-A Heat-curable epoxy-amine anti-seepage sealant HENKEL KGAA 2013-07-31 CN claimed
US-20100300472-A1 METHOD FOR STRAIGHTENING KERATINOUS FIBERS USING HEATING MEANS AND AN AROMATIC COMPOUND L'OREAL S.A. (FR) 2010-12-02 US claimed
US-20100168279-A1 THERMALLY CURABLE EPOXY-AMINE BARRIER SEALANTS HENKEL AG & CO. KGAA (DE) 2010-07-01 US claimed
CN-101405321-A Heat Curable Epoxy-Amine Barrier Sealants NAT STARCH CHEM INVEST (US) 2009-04-08 CN claimed
EP-2001924-A1 THERMALLY CURABLE EPOXY-AMINE BARRIER SEALANTS National Starch and Chemical Investment Holding Corporation (US) 2008-12-17 EP claimed
WO-2007114822-A1 THERMALLY CURABLE EPOXY-AMINE BARRIER SEALANTS NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION (US) 2007-10-11 WO claimed
US-4487975-A Etherification of phenols RHONE-POULENC INDUSTRIES (FR) 1984-12-11 US claimed
EP-3704090-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-05-27 EP disclosed
US-4017508-A POLYMERS EASTMAN KODAK COMPANY (US) 1977-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200205541-A1 METHOD FOR STRAIGHTENING KERATINOUS FIBERS USING HEATING MEANS AND AN AROMATIC COMPOUND KRT18, TUBB4A, TUBB4B HSD17B10 501/4885TSHR 4707/4885HPGD 1754/4885
US-20100300472-A1 METHOD FOR STRAIGHTENING KERATINOUS FIBERS USING HEATING MEANS AND AN AROMATIC COMPOUND KRT18, TUBB4A, TUBB4B HSD17B10 501/4885TSHR 4707/4885HPGD 1754/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.