Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.49 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.36 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
| ▸ | LDHB | P07195 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23387416 | 0.94 | GABRA1 (0.53) | SHBGGABRA1GABRB2HMGB1CXCL12 | |
| SCHEMBL38650833 | 0.94 | GABRA1 (0.53) | SHBGGABRA1GABRB2HMGB1CXCL12 | |
| SCHEMBL8186747 | 0.82 | CA1 (0.46) | SHBGGABRA1GABRB2HMGB1CXCL12 | |
| SCHEMBL1538588 | 0.82 | GABRA1 (0.61) | GABRA1GABRB2NR3C1PGRESR1 | |
| SCHEMBL11679976 | 0.79 | ALOX15 (0.50) | SHBGGABRA1GABRB2HMGB1CXCL12 | |
| SCHEMBL16501712 | 0.78 | SHBG (0.42) | SHBGGABRA1GABRB2PTGS1PTGS2 | |
| SCHEMBL26113500 | 0.78 | GABRA1 (0.39) | SHBGGABRA1GABRB2HMGB1CXCL12 | |
| SCHEMBL16182676 | 0.78 | SHBG (0.50) | SHBGGABRA1GABRB2HMGB1CXCL12 | |
| SCHEMBL5588281 | 0.77 | GABRA1 (0.60) | GABRA1GABRB2NR3C1PGRESR1 | |
| SCHEMBL6934299 | 0.77 | GABRA1 (0.47) | SHBGGABRA1GABRB2NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011857-A | Administering 2,4-di-isobutyl-6-(n,n-dimethylaminomethyl)-phenol; antiinflammatory agent, alleviating psoriasis, diabetes, atheroschlerosis | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-30 | — | — | US | claimed |
| EP-0284879-A2 | Method of inhibiting interleukin-1 release | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-05 | — | — | EP | claimed |
| US-20030092684-A1 | Compositions and methods for treating hemorrhagic virus infections and other disorders | ANTIBODY SYSTEMS, INC. | 2003-05-15 | — | — | US | disclosed |
| US-20020077276-A1 | Compositions and methods for treating hemorrhagic virus infections and other disorders | ANTIBODY SYSTEMS, INC. | 2002-06-20 | — | — | US | disclosed |
| EP-1171163-A1 | COMPOSITIONS CONTAINING TETRACYCLINES FOR TREATING HEMORRHAGIC VIRUS INFECTIONS AND OTHER DISORDERS | Antibody Systems, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000064479-A1 | COMPOSITIONS CONTAINING TETRACYCLINES FOR TREATING HEMORRHAGIC VIRUS INFECTIONS AND OTHER DISORDERS | ANTIBODY SYSTEMS, INC. (US) | 2000-11-02 | — | — | WO | disclosed |
| EP-0627438-B1 | METHANEDIPHOSPHONATE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND PHARMACEUTICAL USE THEREOF | TORAY INDUSTRIES (JP) | 1999-01-13 | — | — | EP | disclosed |
| US-5565440-A | ANTIINFLAMMATORY, ANTIPYRITIC, ANALGESIC, ANTIRHEUMATIC, ANTIARTHRITIC OR ANTIOSTEOPROSIS AGENT | TORAY INDUSTRIES, INC. (JP) | 1996-10-15 | — | — | US | disclosed |
| US-5034412-A | Antiinflammatory agents, skin disorders, antidiabetic agents or antiatherosclerosis agents | MERRELL DOW PHARMACUETICALS INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-5011857-A | Administering 2,4-di-isobutyl-6-(n,n-dimethylaminomethyl)-phenol; antiinflammatory agent, alleviating psoriasis, diabetes, atheroschlerosis | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-30 | — | — | US | disclosed |
| EP-0284879-A3 | METHOD OF INHIBITING INTERLEUKIN-1 RELEASE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-10-17 | — | — | EP | disclosed |
| US-4870101-A | TETRAETHYLTHIURAM DISULFIDE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-26 | — | — | US | disclosed |
| EP-0284879-A2 | Method of inhibiting interleukin-1 release | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020077276-A1 | Compositions and methods for treating hemorrhagic virus infections and other disorders | IL1R1, TNF, IL1A | SHBG 651/4885GABRA1 2759/4885GABRB2 4149/4885 |
| US-20030092684-A1 | Compositions and methods for treating hemorrhagic virus infections and other disorders | CCL11, SSB, TNF | SHBG 702/4885GABRA1 4695/4885GABRB2 4708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.