SCHEMBL70342 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	TSHR	P16473	1/20	0.66

▸	NPC1	O15118	3/20	0.57

▸	RAB9A	P51151	3/20	0.57

▸	ALDH1A1	P00352	2/20	0.57

▸	MITF	O75030	1/20	0.57

▸	HTT	P42858	1/20	0.57

▸	SMN1; SMN2	Q16637	1/20	0.57

▸	POLB	P06746	1/20	0.54

▸	MAPT	P10636	1/20	0.54

▸	MEN1	O00255	4/20	0.54

▸	KMT2A	Q03164	4/20	0.54

▸	GAA	P10253	2/20	0.53

▸	L3MBTL1	Q9Y468	1/20	0.53

▸	TP53	P04637	1/20	0.51

▸	HSD17B10	Q99714	1/20	0.51

▸	RORC	P51449	1/20	0.50

▸	HPGD	P15428	1/20	0.50

▸	CRHBP	P24387	1/20	0.50

▸	CRHR2	Q13324	1/20	0.50

▸	SLC1A3	P43003	1/20	0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL679125	0.90	TSHR (0.69)	TSHRALDH1A1SMN1; SMN2MAPTGAA
Hydrochloric Acid SCHEMBL7130171	0.89	TSHR (0.67)	TSHRNPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL13312439	0.85	ALDH1A1 (0.62)	NPC1RAB9AALDH1A1MITFHTT
SCHEMBL1233439	0.84	HDAC1 (0.66)	ALDH1A1POLBMAPTGAATP53
SCHEMBL8142603	0.83	TSHR (0.73)	TSHRALDH1A1POLBMAPTMEN1
SCHEMBL7821728	0.83	TSHR (0.77)	TSHRNPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL72371	0.82	WNT3A (0.55)	TSHRMAPK1
SCHEMBL11079563	0.82	RAB9A (0.71)	TSHRNPC1RAB9AALDH1A1MITF
SCHEMBL9863064	0.81	TSHR (0.69)	TSHRRAB9AALDH1A1POLBMAPT
SCHEMBL11429211	0.81	TSHR (0.69)	TSHRNPC1RAB9AALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-8129376-B2	Piperidine derivatives as inhibitors of stearoyl-CoA desaturase	AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN)	2012-03-06	—	—	US	disclosed
US-20120004213-A1	NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE	FOREST LABORATORIES HOLDINGS LIMITED (BM)	2012-01-05	—	—	US	disclosed
US-20120004213-A1	NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE	FOREST LABORATORIES HOLDINGS LIMITED (BM)	2012-01-05	—	—	US	disclosed
US-8039463-B2	Piperazine derivatives as inhibitors of stearoyl-CoA desaturase	FOREST LABORATORIES HOLDINGS LIMITED (BM)	2011-10-18	—	—	US	disclosed
US-8039463-B2	Piperazine derivatives as inhibitors of stearoyl-CoA desaturase	FOREST LABORATORIES HOLDINGS LIMITED (BM)	2011-10-18	—	—	US	disclosed
US-8039463-B2	Piperazine derivatives as inhibitors of stearoyl-CoA desaturase	FOREST LABORATORIES HOLDINGS LIMITED (BM)	2011-10-18	—	—	US	disclosed
EP-2307023-A1	NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE	Forest Laboratories Holdings Limited (BM)	2011-04-13	—	—	EP	disclosed
EP-2268143-A2	NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE	Forest Laboratories Holdings Limited (BM)	2011-01-05	—	—	EP	disclosed
WO-2009117659-A1	NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE	FOREST LABORATORIES HOLDINGS LIMITED (BM)	2009-09-24	—	—	WO	disclosed
WO-2009117659-A1	NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE	FOREST LABORATORIES HOLDINGS LIMITED (BM)	2009-09-24	—	—	WO	disclosed
WO-2009117676-A2	NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE	FOREST LABORATORIES HOLDINGS LIMITED (BM)	2009-09-24	—	—	WO	disclosed
US-20090239810-A1	NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE	FOREST LABORATORIES HOLDINGS LIMITED (BM)	2009-09-24	—	—	US	disclosed
US-20090239848-A1	NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE	FOREST LABORATORIES HOLDINGS LIMITED (BM)	2009-09-24	—	—	US	disclosed
US-20090239848-A1	NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE	FOREST LABORATORIES HOLDINGS LIMITED (BM)	2009-09-24	—	—	US	disclosed
US-20090239848-A1	NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE	FOREST LABORATORIES HOLDINGS LIMITED (BM)	2009-09-24	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20090239848-A1	NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE	SCD, SCD5, FADS2	TSHR 4601/4885NPC1 206/4885RAB9A 4065/4885
US-20090239810-A1	NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE	SCD, SCD5, FADS2	TSHR 4631/4885NPC1 201/4885RAB9A 3858/4885
US-20120004213-A1	NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE	SCD, SCD5, FADS2	TSHR 4601/4885NPC1 206/4885RAB9A 4065/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.