Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6402819 | 0.71 | POLB (0.42) | POLBHTTMAPTKMT2AMEN1 | |
| SCHEMBL7034667 | 0.69 | POLB (0.41) | POLBHTTMAPTATMKMT2A | |
| SCHEMBL6777717 | 0.69 | POLB (0.59) | POLBMAPTKMT2AMEN1S100A4 | |
| SCHEMBL11728712 | 0.68 | AKR1C3 (0.42) | HTTMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL6256201 | 0.68 | MAPT (0.44) | HTTMAPTATMKMT2AMEN1 | |
| SCHEMBL7972358 | 0.68 | CYP2A6 (0.38) | HTTKMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL2958656 | 0.67 | CA1 (0.36) | HTTMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL4355515 | 0.67 | POLB (0.44) | POLBHTTMAPTKMT2AMEN1 | |
| SCHEMBL8631968 | 0.66 | POLB (0.42) | POLBHTTMAPTKMT2AMEN1 | |
| SCHEMBL6050865 | 0.65 | MAPT (0.38) | POLBHTTMAPTATMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3383875-B1 | 3-PYRIMIDINYL PYRROLO [2,3-B] PYRIDINE AS ANTICANCER AGENTS AND THE PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2022-02-09 | — | — | EP | claimed |
| EP-3383875-A1 | 3-PYRIMIDINYL PYRROLO [2,3-b] PYRIDINE AS ANTICANCER AGENTS AND THE PROCESS FOR THE PREPARATION THEREOF | Council Of Scientific & Industrial Research (IN) | 2018-10-10 | — | — | EP | claimed |
| WO-2017094026-A1 | 3-PYRIMIDINYL PYRROLO [2,3-B] PYRIDINE AS NEW ANTICANCER AGENTS AND THE PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-06-08 | — | — | WO | claimed |
| CN-112239472-B | Organic compound, organic light emitting diode including the same, and organic light emitting device | 乐金显示有限公司 | 2023-06-16 | — | — | CN | disclosed |
| EP-3383875-B1 | 3-PYRIMIDINYL PYRROLO [2,3-B] PYRIDINE AS ANTICANCER AGENTS AND THE PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2022-02-09 | — | — | EP | disclosed |
| EP-3383875-A1 | 3-PYRIMIDINYL PYRROLO [2,3-b] PYRIDINE AS ANTICANCER AGENTS AND THE PROCESS FOR THE PREPARATION THEREOF | Council Of Scientific & Industrial Research (IN) | 2018-10-10 | — | — | EP | disclosed |
| WO-2017094026-A1 | 3-PYRIMIDINYL PYRROLO [2,3-B] PYRIDINE AS NEW ANTICANCER AGENTS AND THE PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-06-08 | — | — | WO | disclosed |
| EP-0739336-A1 | GEM-DISUBSTITUTED AZACYCLIC TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1996-10-30 | — | — | EP | disclosed |
| WO-1995019344-A1 | GEM-DISUBSTITUTED AZACYCLIC TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-07-20 | — | — | WO | disclosed |