Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7043722 | 0.96 | MEN1 (0.37) | HTR3APARP1MEN1KMT2A | |
| SCHEMBL7457531 | 0.90 | HTR3A (0.37) | CHRNB2CHRNA4ATRPRKCAPRKCQ | |
| SCHEMBL7041670 | 0.88 | FLT3 (0.42) | CHRNB2CHRNA4ATRPRKCAPRKCQ | |
| SCHEMBL7042010 | 0.88 | FLT3 (0.41) | CHRNB2CHRNA4HTR3AMEN1KMT2A | |
| SCHEMBL7036855 | 0.87 | HTR3A (0.40) | CHRNB2CHRNA4PRKCAPRKCQPRKCD | |
| SCHEMBL7044695 | 0.87 | HTR3A (0.40) | CHRNB2CHRNA4PRKCAPRKCQPRKCD | |
| SCHEMBL7045753 | 0.86 | HTR3A (0.38) | CHRNB2CHRNA4HTR3AMEN1KMT2A | |
| SCHEMBL7046777 | 0.85 | HTR3A (0.39) | CHRNB2CHRNA4HTR3A | |
| SCHEMBL7042034 | 0.84 | PRKCQ (0.39) | PRKCQMEN1KMT2A | |
| SCHEMBL7037841 | 0.84 | HTR3A (0.38) | HTR3APARP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |