SCHEMBL7039059

SCHEMBL7039059

COC(=O)c1cc(COCC2CCN(C(C)=N)CC2)cc(-c2cccc(C(=N)N)c2)c1

nearest known ligand 0.50

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
F10 P00742 17/20 0.50
F2 P00734 11/20 0.50
PRSS1 P07477 5/20 0.43
PLG P00747 4/20 0.42
PLAU P00749 4/20 0.42
ST14 Q9Y5Y6 4/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7039793 0.89 HRH3 (0.43) F10F2PRSS1PLGPLAU
SCHEMBL6130337 0.86 F10 (0.51) F10F2PRSS1PLGPLAU
SCHEMBL7063308 0.86 CHRM3 (0.40) F10F2PRSS1PLGPLAU
SCHEMBL6751808 0.80 CCR5 (0.44) PLAU
SCHEMBL7659032 0.79 PRSS1 (0.49) F10F2PRSS1PLG
SCHEMBL6130348 0.77 F10 (0.50) F10F2PRSS1PLGPLAU
Hydrochloric Acid SCHEMBL6130310 0.76 F10 (0.49) F10F2PRSS1PLGPLAU
SCHEMBL6752053 0.76 F10 (0.42) F10F2PRSS1PLGPLAU
SCHEMBL7667899 0.76 LOXL2 (0.56) F10F2PRSS1PLG
Hydrochloric Acid SCHEMBL6130303 0.76 F10 (0.49) F10F2PRSS1PLGPLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030203935-A1 Cyanobiphenyl derivatives TEIJIN LIMITED 2003-10-30 US disclosed
US-6538137-B1 Blood-coagulation factor X inhibitors TEIJIN LIMITED (JP) 2003-03-25 US disclosed
EP-1179527-A1 CYANOBIPHENYL DERIVATIVES TEIJIN LIMITED (JP) 2002-02-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030203935-A1 Cyanobiphenyl derivatives F9, F12, F11 F10 7/4885F2 4/4885PRSS1 633/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.