Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MMP2 | P08253 | 4/20 | 0.55 |
| ▸ | MMP8 | P22894 | 4/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1514533 | 0.84 | MEN1 (0.67) | MEN1KMT2AHSP90AA1NPSR1L3MBTL1 | |
| SCHEMBL28810693 | 0.77 | L3MBTL1 (0.79) | MEN1KMT2AHSP90AA1TLR9NPSR1 | |
| SCHEMBL27955203 | 0.75 | EGFR (0.71) | MEN1KMT2AHSP90AA1TLR9L3MBTL1 | |
| SCHEMBL27955196 | 0.75 | EGFR (0.71) | MEN1KMT2AHSP90AA1TLR9NPSR1 | |
| SCHEMBL27955191 | 0.75 | EGFR (0.71) | MEN1KMT2AHSP90AA1TLR9NPSR1 | |
| SCHEMBL27955195 | 0.75 | EGFR (0.71) | MEN1KMT2AHSP90AA1TLR9MMP2 | |
| SCHEMBL3600995 | 0.74 | PKM (0.62) | MEN1KMT2AHSP90AA1TLR9NPSR1 | |
| SCHEMBL28205908 | 0.74 | NPSR1 (0.74) | MEN1KMT2ANPSR1POLBCA1 | |
| SCHEMBL10016510 | 0.72 | POLB (1.00) | MEN1KMT2ANPSR1POLBCA1 | |
| SCHEMBL3594537 | 0.72 | PKM (0.63) | MEN1KMT2AHSP90AA1TLR9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292601-A2 | NAALADASE INHIBITORS FOR TREATING RETINAL DISORDERS AND GLAUCOMA | GUILFORD PHARMACEUTICALS INC. (US) | 2003-03-19 | — | — | EP | claimed |
| WO-2001092274-A2 | NAALADASE INHIBITORS FOR TREATING RETINAL DISORDERS AND GLAUCOMA | GUILFORD PHARMACEUTICALS INC. (US) | 2001-12-06 | — | — | WO | claimed |