Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.80 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.75 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | MAOA | P21397 | 2/20 | 0.60 |
| ▸ | MAOB | P27338 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 5/20 | 0.58 |
| ▸ | TERT | O14746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | XBP1 | P17861 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28205908 | 0.82 | NPSR1 (0.74) | POLBKMT2ANPSR1MEN1KDM4E | |
| SCHEMBL3601300 | 0.75 | BRAF (0.83) | — | |
| SCHEMBL3595653 | 0.74 | BRAF (0.68) | POLBPKM | |
| SCHEMBL3638755 | 0.74 | PKM (0.65) | POLBPKM | |
| SCHEMBL3600434 | 0.73 | PKM (0.63) | POLBPKM | |
| SCHEMBL3586458 | 0.73 | PKM (0.66) | POLBPKM | |
| SCHEMBL7039863 | 0.72 | MEN1 (0.61) | POLBKMT2ANPSR1MEN1KDM4E | |
| SCHEMBL18248281 | 0.72 | TERT (1.00) | POLBKMT2ATERT | |
| SCHEMBL14540795 | 0.72 | NPSR1 (0.73) | POLBKMT2ANPSR1MEN1CA1 | |
| SCHEMBL27918012 | 0.71 | MAOB (0.64) | POLBKMT2ANPSR1MEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140255386-A1 | MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140255386-A1 | MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-09-11 | — | — | US | disclosed |
| WO-2013019469-A1 | MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME | THE WISTAR INSTITUTE (US) | 2013-02-07 | — | — | WO | disclosed |
| US-20130023498-A1 | MicroRNA Modulators and Method for Identifying and Using the Same | The Wistar Institute and North Carolina State University | 2013-01-24 | — | — | US | disclosed |
| US-20120010177-A1 | MicroRNA Modulators and Method for Identifying And Using The Same | The Wistar Institute / North Carolina State University (US) | 2012-01-12 | — | — | US | disclosed |
| US-20120010177-A1 | MicroRNA Modulators and Method for Identifying And Using The Same | The Wistar Institute / North Carolina State University (US) | 2012-01-12 | — | — | US | disclosed |
| US-20100196357-A1 | Microrna modulators and method for identifying and using the same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-08-05 | — | — | US | disclosed |
| US-20100196357-A1 | Microrna modulators and method for identifying and using the same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100196357-A1 | Microrna modulators and method for identifying and using the same | AGO2, RNASE1, TRDMT1 | POLB 2386/4885KMT2A 1688/4885NPSR1 3040/4885 |
| US-20130023498-A1 | MicroRNA Modulators and Method for Identifying and Using the Same | AGO2, RNASE1, TRDMT1 | POLB 2386/4885KMT2A 1688/4885NPSR1 3040/4885 |
| US-20120010177-A1 | MicroRNA Modulators and Method for Identifying And Using The Same | AGO2, RNASE1, TRDMT1 | POLB 2386/4885KMT2A 1688/4885NPSR1 3040/4885 |
| US-20140255386-A1 | MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME | AGO2, RNASE1, TRDMT1 | POLB 2386/4885KMT2A 1688/4885NPSR1 3040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.